A Collaborative Study of the Aetiology of Acute Respiratory Infections in Britain 1961-4

Tm, Banham

doi:10.1136/bmj.2.5457.319

Cited by 46 publications

(2 citation statements)

References 12 publications

(9 reference statements)

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“…Bronchiolitis was mainly considered an RSV infection, with recovery in up to 73% of patients with confirmed cases ( 30 ). Lower RSV recovery rates were seen in older children ( 17 , 18 , 21 , 22 , 24 , 27 ). In the 1990s, viral detection rates increased to 75% to 85%, mainly as result of the increased detection of rhinoviruses by PCR ( 3 , 5 ).…”

Section: Discussionmentioning

confidence: 92%

Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children

Jartti

Lehtinen

Vuorinen

et al. 2004

Emerg. Infect. Dis.

311

331

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We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages >3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.

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Section: Discussionmentioning

confidence: 92%

Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children

Jartti

Lehtinen

Vuorinen

et al. 2004

Emerg. Infect. Dis.

311

331

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“…A number of viruses and atypical organisms capable of causing respiratory illnesses were identified over the following 20 years. The big explosion in the identification of respiratory viruses occurred in the 1950 and 1960's with identification of respiratory syncytial virus, rhinovirus, adenovirus, parainfluenza, and others (1,(25)(26)(27)(28)(29)(30)(31)(32)(33). While a link was made between parainfluenza II and croup it was soon recognized that the majority of parainfluenza virus II infections were relatively mild respiratory illnesses while many other viruses were also able to cause croup.…”

Section: Recognition Of the Role Of Viruses In Acute Lower Respiratormentioning

confidence: 99%

Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That

Douros

Everard

2020

Front. Pediatr.

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Newly identified human rhinoviruses: molecular methods heat up the cold viruses

Arden

Mackay

2010

Reviews in Medical Virology

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Human rhinovirus (HRV) infections cause at least 70% of virus-related wheezing exacerbations and cold and flu-like illnesses. They are associated with otitis media, sinusitis and pneumonia. Annually, the economic impact of HRV infections costs billions in healthcare and lost productivity. Since 1987, 100 officially recognised HRV serotypes reside in two genetically distinct species; HRV A and HRV B, within the genus Enterovirus, family Picornaviridae. Sequencing of their approximately 7kb genomes was finalised in 2009. Since 1999, many globally circulating, molecularly-defined 'strains', perhaps equivalent to novel serotypes, have been discovered but remain uncharacterised. Many of these currently unculturable strains have been assigned to a proposed new species, HRV C although confusion exists over the membership of the species. There has not been sufficient sampling to ensure the identification of all strains and no consensus criteria exist to define whether clinical HRV detections are best described as a distinct strain or a closely related variant of a previously identified strain (or serotype). We cannot yet robustly identify patterns in the circulation of newly identified HRVs (niHRVs) or the full range of associated illnesses and more data are required. Many questions arise from this new found diversity: what drives the development of so many distinct viruses compared to other species of RNA viruses? What role does recombination play in generating this diversity? Are there species- or strain-specific circulation patterns and clinical outcomes? Are divergent strains sensitive to existing capsid-binding antivirals? This update reviews the findings that trigger these and other questions arising during the current cycle of intense rhinovirus discovery.

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A Collaborative Study of the Aetiology of Acute Respiratory Infections in Britain 1961-4

Cited by 46 publications

References 12 publications

Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children

Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children

Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That

Newly identified human rhinoviruses: molecular methods heat up the cold viruses

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