A Collaborative Nationwide Lymphoma Study in Lebanon: Incidence of Various Subtypes and Analysis of Associations with Viruses

Otrock, Zaher K.; Saab, Jad; Aftimos, Georges; Nasr, Fady; Farhat, Fadi; Khairallah, Saad; Abadjian, Gerard; Ghosn, Marwan; Sidani, Hassan; Ibrahim, Ahmad; Tawil, Ayman; Ghorra, Claude; Meguerian, Zarouhie; Mokaddem, Walid; Dayeh, Walid; Salem, Ziad; Chahine, Georges; Bitar, Nizar; Mugharbel, Anas; Makdessi, Joseph; Khater, Christina; Hajj, Mirna El; Gerges, Dany Abi; Sfeir, Charles; Kattan, Joseph; Ibrahim, Khaled; Saade, Michel; Sadek, Hussein; Mahfouz, Rami; Kharfan‐Dabaja, Mohamed A.; Zaatari, Ghazi; Bazarbachi, Ali

doi:10.1007/s12253-013-9634-0

Cited by 13 publications

(10 citation statements)

References 65 publications

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“…A review of other published studies from NAF/ME/IN (Castella et al , ; Almasri et al , ; Isikdogan et al , ; Abdel‐Fattah & Yassine, ; Sahni & Desai, ; Akhtar et al , ; Goldman et al , ; Ameen et al , ; Mozaheb et al , ; Yaqo et al , ; Arora et al , ; Otrock et al , ; Mondal et al , ) generally showed relative frequencies of NHL subtypes similar to our study (Table ). The most common lymphoma in all of these studies was DLBCL, ranging from 31% in Egypt (Abdel‐Fattah & Yassine, ) to 59% in the United Arab Emirates (UAE) (Castella et al , ), with most studies reporting a frequency above 40%.…”

Section: Discussionmentioning

confidence: 87%

“…The frequency of CLL/SLL was lowest in UAE (1%) (Castella et al , ) and highest in Iran (23·9%) (Mozaheb et al , ). The frequency of T‐NHL ranged from 1·9% in Iran (Mozaheb et al , ) to 18·4% in Lebanon (Otrock et al , ) , and frequencies higher than 10% were reported from Jordan (Almasri et al , ), Saudi Arabia (Akhtar et al , ) and India (Sahni & Desai, ; Arora et al , ; Mondal et al , ). These highly variable findings point to the need for systematic, large‐scale studies such as this in order to better understand these differences.…”

Section: Discussionmentioning

confidence: 99%

“…The epidemiological risk factors contributing to these variations are unclear, but are probably a combination of genetic, cultural and lifestyle factors, as well socioeconomic, resource and environmental factors that are specific for each region (Chiu & Weisenburger, ; Morton et al , ; Evens & Chiu, ). A number of small studies conducted in North Africa, the Middle East and India (NAF/ME/IN) have reported on the relative frequencies of NHL subtypes in various countries (Castella et al , ; Almasri et al , ; Isikdogan et al , ; Abdel‐Fattah & Yassine, ; Sahni & Desai, ; Akhtar et al , ; Goldman et al , ; Ameen et al , ; Mozaheb et al , ; Yaqo et al , ; Arora et al , ; Otrock et al , ; Mondal et al , ), but no systematic, large‐scale study of the distribution of NHL subtypes in this region has been published to date. The aim of this study was to assess the relative frequencies of NHL subtypes in NAF/ME/IN and compare the findings to a previously accrued cohort from North America (NA) (Anderson et al , ).…”

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confidence: 99%

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Relative frequency of non‐Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases

Perry

Diébold²,

Nathwani

et al. 2015

Br J Haematol

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Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Relative frequency of non‐Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases

Perry

Diébold²,

Nathwani

et al. 2015

Br J Haematol

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“…This will be followed by non-Hodgkin disease with 20.0 cases per 100,000. A recent nationwide lymphoma study in Lebanon noted an increase in lymphomas worldwide over the past decade and argued for the need of large scale studies to assess the increasing rates [13]. Worldwide, an annual increase of 1-2% in non-Hodgkin lymphoma incidence has been noted, mostly in older people aged over 55 years [14].…”

Section: Discussionmentioning

confidence: 99%

Cancer trends in Lebanon: a review of incidence rates for the period of 2003–2008 and projections until 2018

Shamseddine

Saleh

Charafeddine

et al. 2014

Popul Health Metrics

104

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Background: The analysis of cancer incidence trends is essential to health care planning. The aim of this study is to examine variations in cancer incidence rates in Lebanon between 2003 and 2008 and use the observed trends to project cancer incidence until 2018. Methods: Using secondary data with a cumulative caseload of 45,753 patients from the National Cancer Registry database of the Ministry of Public Health in Lebanon, we estimated sex-and site-specific incidence of cancer for each year of the six-year period between 2003 and 2008. Logarithmic regressions were fitted to estimate the cancer incidence for the forecast years until 2018.

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“…HL represented 32.7% of all cases of lymphoma diagnosed in Lebanon in 2007. In most patients IgG anti-Epstein-Barr virus were present, but serology for hepatitis C virus (HCV) was negative in 122 tested cases [6].…”

Section: Introductionmentioning

confidence: 99%

Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Mihăilă

2017

IJPPE

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Abstract. The hepatocytolysis raises questions on following therapeutic conduct when it occurs during chemotherapy for Hodgkin's lymphoma, expression of its liver toxicity. But the onset of primary liver Hodgkin's lymphoma, including the form manifested by acute liver failure, poses even greater problems, as in the case of occurrence of vanishing bile duct syndrome -expression of a paraneoplastic syndrome, hemophagocytic lymphohistiocytosis, peliosis hepatis or association of lymphoma with infection with hepatitis viruses or human immunodeficiency virus or different autoimmune diseases. This review summarizes the clinical experience acquired on the relationship between Hodgkin's lymphoma and liver, from the point of view of clinical manifestations, used treatments and clinical evolution. Suggestions on the course of treatment in patients with Hodgkin's lymphoma and liver damage have been formulated starting from the metabolism and elimination of chemotherapy drugs and taking into account the clinical experience of published clinical trials and cases. This review is a synthesis of knowledge obtained in this field, during the time, of therapeutic possibilities and limits, and formulates potential future milestones for research.

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A Collaborative Nationwide Lymphoma Study in Lebanon: Incidence of Various Subtypes and Analysis of Associations with Viruses

Cited by 13 publications

References 65 publications

Relative frequency of non‐Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases

Relative frequency of non‐Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases

Cancer trends in Lebanon: a review of incidence rates for the period of 2003–2008 and projections until 2018

Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

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