A Cohort Study on Associations between Fundus/intraocular Pressure Abnormality and Medical Check-up Items

Wang, Peiping; Ke, Changmin; Yao, Dongying; Fang, Xiaojuan; Luo, Wenxin; Wu, Jianglin; Wang, Juan; Zheng, Can

doi:10.1080/02713683.2020.1826978

Cited by 7 publications

(9 citation statements)

References 25 publications

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“…A number of previous studies have suggested the significant correlation between higher SBP and IOP, 8 , 10 – 12 , 14 , 16 , 17 , 40 – 44 between HbA1c and IOP, 7 , 8 , 10 – 12 , 14 – 16 , 42 , 44 – 46 between BMI and IOP, 6 – 8 , 10 – 12 , 14 – 16 , 42 , 45 between HDL-C and IOP, 47 , 48 and also between smoking habits and IOP. 49 , 50 Conversely, no significant correlation with these variables has been found in this study. These contradicting results would be attributed to the differences of the nature of the studies (cross-sectional or longitudinal) and also the sizes of the studied population.…”

Section: Discussioncontrasting

confidence: 79%

The Association Between Age and Systemic Variables and the Longitudinal Trend of Intraocular Pressure in a Large-Scale Health Examination Cohort

Asaoka

Obana

Murata

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose The detailed effects of age and systemic factors on intraocular pressure (IOP) have not been fully understood because of the lack of a large-scale longitudinal investigation. This study aimed to investigate the effect of various systemic factors on the longitudinal change of IOP. Methods There were a total of 20,909 eyes of 10,471 subjects from a health checkup cohort that were followed up for systemic factors: (i) age at baseline, (ii) sex, (iii) time series body mass index (BMI), (iv) time series smoking habits, (v) time series systolic and diastolic blood pressures (SBP and DBP), and (vi) time series 19 blood examinations (all of the time series data was acquired at each annual visit), along with IOP annually for at least 8 years. Then the longitudinal effect of the systemic factors on the change of IOP was investigated. Results IOP significantly decreased by −0.084 mm Hg/year. BMI, SBP, DBP, smoking habits, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and glycosylated hemoglobin A1c were not significantly associated with the change of IOP. Higher values of age, aspartate aminotransferase, hemoglobin, platelet, and calcium were suggested to be significantly associated with the decrease of IOP, whereas higher alanine aminotransferase, guanosine triphosphate, white blood cell count, red blood cell count, and female gender were significantly associated with the increase of IOP. Conclusions Age, aspartate aminotransferase, hemoglobin, platelet, calcium, alanine aminotransferase, guanosine triphosphate, white blood cell count, red blood cell count, and gender were the systemic variables significantly associated with the change of IOP.

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Section: Discussioncontrasting

confidence: 79%

The Association Between Age and Systemic Variables and the Longitudinal Trend of Intraocular Pressure in a Large-Scale Health Examination Cohort

Asaoka

Obana

Murata

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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“…He et al 11 indicated that the most common TCM syndromes were spleen-kidney yang deficiency and damp-heat phlegm stasis (accounting for 30.47% of the study population); qi-yin deficiency syndrome was found in another 69 patients (11.41%). Wang et al, 12 however, found that qi-yin deficiency occurred most frequently and that the frequency of damp-heat trapping spleen was not significant. In the TCM view of diabetes, yin deficiency and excessive heat do not occupy a dominant position in clinical practice; [14][15][16][17][18] instead, the spleen is seen as the main mover of the disease, the qi as the main rise, the stomach as the main receptor, and the decline to shun.…”

Section: Discussionmentioning

confidence: 95%

“…TCM prescriptions, specific to the treatment of T2DM, for invigorating the spleen, resolving phlegm, tonifying the kidneys, and dehumidifying and activating the blood can help improve lipid metabolism, reduce fat accumulation in vivo, improve circulation, promote the use of nutrients in the body, increase the utilization of insulin in the muscles and other cells, and reduce insulin resistance. 12 The reduction of insulin resistance not only reduces blood sugar but also prevents the occurrence 13 of complications. It has a unique role to play in the treatment of T2DM in the field of TCM.…”

Section: Discussionmentioning

confidence: 99%

The Distribution Pattern of Traditional Chinese Medicine Syndromes in 549 Patients with Type 2 Diabetes

Zhang¹,

Liu²,

Liang³

et al. 2021

DMSO

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Objective This study aimed to summarize the distribution pattern of traditional Chinese medicine (TCM) syndromes in patients with type 2 diabetes mellitus (T2DM). Methods The frequency, characteristics and distribution of all TCM syndromes of 549 patients with T2DM were analyzed. Results The average age of T2DM onset was higher in women than in men (ie, men experienced earlier onset). The distribution of TCM syndromes, in order of frequency, was as follows: damp-heat trapping spleen (including spleen deficiency and dampness, damp heat due to spleen deficiency, and qi weakness due to spleen deficiency) (58.29%), qi-yin deficiency (16.03%), deficiency of yin and excessive heat (12.93%), blood stasis in collaterals (9.41%), and yin-yang deficiency (3.21%). The physical intensity of patients’ occupational activity was mainly light (49.6%), followed by heavy (31.4%) and moderate (19.0%). Conclusion Damp-heat trapping spleen is the most common TCM syndrome in patients with T2DM, with damp heat due to spleen deficiency the most significant subtype. This syndrome tends to occur in people over the age of 60 and those undertaking too much or too little physical activity in their occupational activities. The traditional “three more and one less” symptoms do not adequately describe the clinical symptoms of T2DM.

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“…Atherosclerosis, which progresses with age, is assumed to result from macrophage activation and mitochondrial de ciency in the vascular endothelial cells 12 and can be accelerated by high serum cholesterol levels and hypertension. [13][14][15] This correlation was observed in both the retinal-and choroidal-disease groups, suggesting that systemic vascular conditions, such as age-related systemic atherosclerosis, in patients with either disease may be similar. In fact, hypertension is a known risk factor of most diseases included in the current study.…”

Section: Discussionmentioning

confidence: 99%

Retinal circulation time/arm-to-retina time ratio in the fluorescein angiography to evaluate retina-specific hemodynamics

Mushiga

Nagai

Ozawa

2022

Preprint

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To evaluate dynamic circulatory flow in the retinal or choroidal circulatory disease, we retrospectively reviewed medical charts of 128 eyes of 128 patients who underwent video recorded fluorescein angiography (FA), at Department of Ophthalmology, St Luke’s International Hospital, between April and September 2020. Mean age was 64.2 ± 14.0 (range, 37–93) years, and 87 (67.9%) patients were men. Mean arm-to-retina (AR) time was 16.2 ± 4.1 s, and mean retinal circulation (RC) time was 10.9 ± 3.3 s. Mean RC time/AR time (RC/AR) ratio was 0.69 ± 0.22. AR time was correlated with age, whereas RC time was not. RC time was positively correlated with AR time (R = 0.360, P = 0.017). Moreover, mean RC time was significantly longer, and RC/AR ratio was greater, in the retinal-disease group after adjusting for age and sex. Patients who had an RC/AR ratio ≥ 0.8 more frequently presented with retinal diseases. Given that AR time reflects systemic hemodynamics, RC time, which reflects local circulatory fluency, was influenced by the systemic circulatory condition. Moreover, RC/AR ratio revealed that circulatory changes peculiar to the retina may also be involved in retinal-disease pathogenesis. This study may help elucidate the mechanisms of retinal diseases and assist in diagnosis, although further studies are required.

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A Cohort Study on Associations between Fundus/intraocular Pressure Abnormality and Medical Check-up Items

Cited by 7 publications

References 25 publications

The Association Between Age and Systemic Variables and the Longitudinal Trend of Intraocular Pressure in a Large-Scale Health Examination Cohort

The Association Between Age and Systemic Variables and the Longitudinal Trend of Intraocular Pressure in a Large-Scale Health Examination Cohort

The Distribution Pattern of Traditional Chinese Medicine Syndromes in 549 Patients with Type 2 Diabetes

Retinal circulation time/arm-to-retina time ratio in the fluorescein angiography to evaluate retina-specific hemodynamics

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