2008
DOI: 10.1186/1476-069x-7-37
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A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio

Abstract: Background: Polychlorinated biphenyls (PCBs) are ubiquitous industrial chemicals that persist in the environment and in human fatty tissue. PCBs are related to a class of compounds known as dioxins, specifically 2,3,7,8-TCDD (tetrachloro-dibenzodioxin), which has been implicated as a cause of altered sex ratio, especially in relation to paternal exposures.

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Cited by 42 publications
(34 citation statements)
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References 48 publications
(46 reference statements)
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“…Thus, the associations found may be a reflection of anxieties associated with perceived exposures on deployment [66]. For example, Stuart et al [88] found that Gulf War soldiers who reported higher levels of combat exposures or combat stress were more likely to believe they had been exposed to chemical/biological weapons. It may be useful for the ADF to consider providing serving members with information about potential hazards in the MEAO to dispel any misunderstandings and to enhance through training their capacity to recognise and combat possible hazards while on deployment.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the associations found may be a reflection of anxieties associated with perceived exposures on deployment [66]. For example, Stuart et al [88] found that Gulf War soldiers who reported higher levels of combat exposures or combat stress were more likely to believe they had been exposed to chemical/biological weapons. It may be useful for the ADF to consider providing serving members with information about potential hazards in the MEAO to dispel any misunderstandings and to enhance through training their capacity to recognise and combat possible hazards while on deployment.…”
Section: Discussionmentioning
confidence: 99%
“…In rats treated with TCDD on gestational day 14, the maternal lowest-observed-averse-effect-level for immunosuppression in male offspring (median; 0.1 μg/kg) was lower than that in female offspring (median; 0.3 μg/kg) (Luebke et al, 2006). A few human studies have shown gender-specific differences in the effects of prenatal exposure to DLCs with respect to gender ratio (Hertz-Picciotto et al, 2008;Mocarelli et al, 1996), lymphocyte subset rate (Nagayama et al, 2007), and birth weight (Sonneborn et al, 2008;Konishi et al, 2009). …”
Section: Discussionmentioning
confidence: 99%
“…[8,9,[26][27][28][29][30][31][32][33] As information on SES is not available from the TCR, census tract-level poverty was used as a proxy for SES. Specifically, information on the proportion of households with an income lower than the poverty level for each census tract was obtained from the 2000 U.S. Census.…”
Section: Covariatesmentioning
confidence: 99%