A cocktail solution for the ex vivo preservation and perfusion of the lung; Shehata solution

Abstract

The importance of lung transplantation is increasing, being the practical solution for the end stage pulmonary failure. ex vivo graft preservation is an essential step in the transplantation surgery that consists of hypothermic preservation and or normothermic perfusion.There are many preservation solutions that are used for the ex vivo lung preservation and are commercially available or institutionally used. Based on the clinical results, the effective preservation determines the clinical outcome of the transplantation surgery.Despite the great progress in the development of the preservation solutions, there is a continuous interest at further development in order to achieve the perfectionism of the technique. This paper describes an innovative solution to be used for the hypothermic graft preservation and the ex vivo lung perfusion, trying to apply the advantages of the other solutions, while avoiding the disadvantages, based on the translational medical knowledge.