A Coagulation Defect and Its Treatment with Heparin in Plasmodium knowlesi Malaria in Rhesus Monkeys

Dennis, Lewis H.; Eichelberger, James W.; Doenhoff, Albert E Von; Me, Conrad

doi:10.1093/milmed/131.suppl_9.1107

Cited by 17 publications

(6 citation statements)

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“…Activation of the intrinsic pathway is often associated with activation of the fibrinolytic system. Previous studies in severe malaria have shown consistently elevated concentrations of fibrin degradation products, usually with increased levels of fibrinogen, suggesting increased fibrinogen turnover [1,14,15]. However, there is a paucity of reports regarding the study of different components of fibrinolytic system.…”

Section: Inhibitors Of Blood Coagulationmentioning

confidence: 99%

“…Altered hemostasis associated with plasmodium falciparum infection has been reported in the past. Consumption of clotting PATIENTS AND METHODS Patients factors and high levels of fibrinogen degradation product (FDP) were found in some studies [1][2][3]. However, other This study includes 100 adult patients, both male and investigations have reported only isolated thrombocyto-female, presenting at the New Civil Hospital, Surat, India penia without any alteration in the coagulation system fulfilling the following criteria.…”

Section: Introductionmentioning

confidence: 99%

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Fibrinolysis, inhibitors of blood coagulation, and monocyte derived coagulant activity in acute malaria

et al. 1997

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Different parameters of fibrinolytic systems like t-PA, PAI, D-dimer, and inhibitors of blood coagulation, i.e., protein C (PC), protein S(PS), and antithrombin III (AT-III), have been studied in cases of acute malaria due to Plasmodium falciparum and plasmodium vivax infection, and these patients were followed up. It was observed that the plasma PAI-1 was very high in cases of P. falciparum malaria infection as compared to normal controls and P. vivax infection. The changes in complicated cases of P. falciparum were remarkable as compared to uncomplicated ones. The PC, PS, and AT-III levels were also low in P. falciparum, particularly so in complicated cases, and were normal in P. vivax infection. The factor VIII R:Ag levels were invariably high in acute malaria. On follow-up of some of these cases the values came back to normal after the antiparasite treatment. The monocyte procoagulant activity was found to be significantly higher in P. falciparum infection as compared to that of P. vivax infection. All these findings therefore contribute towards the production of a hypercoagulable state in P. falciparum infection and partly explain the complications of P. falciparum infection like cerebral malaria.

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Section: Inhibitors Of Blood Coagulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fibrinolysis, inhibitors of blood coagulation, and monocyte derived coagulant activity in acute malaria

et al. 1997

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“…A fine fibrin deposit has been described around them. BRITISH MEDICAL JOURNAL 717 Recently a reduction of coagulation factors in the blood in animal malaria and in United States military personnel suffering from chloroquine-resistant malaria has been described, the findings being suggestive of increased coagulation, and it has been postulated that this may be precipitated by phospholipids released from the stroma of destroyed erythrocytes (Dennis et al, 1966). An increase of circulating fibrinolysis in African populations has been suggested as a possible explanation of the very low incidence of coronary thrombosis in this part of the world.…”

Section: Cerebral Malariamentioning

confidence: 99%

Pathology of malaria in West Africa.

Edington¹

1967

BMJ

110

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“…An entirely different mechanism for the production of thrombocytopenia was postulated by Devakul et al (1966) and by Dennis, Conrad, and their associates (Dennis et al, 1966(Dennis et al, , 1967Dennis and Conrad, 1968;Conrad, 1969). They felt that the platelets were being removed from the circulation by consumption in intravascular coagulation, and presented convincing evidence by showing depletion of coagulation factors and the presence of fibrinogen degradation products as well as thrombocytopenia.…”

Section: Bone Marrow Examinationmentioning

confidence: 99%