A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology

Abstract

As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention and proper treatment. To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35 μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided by a commercialized semiconductor foundry. Because of the advantages of CMOS system-on-chip (SoC) technologies, the poly-Si NW biosensor is integrated with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE), a successive approximation analog-to-digital converter (SAR ADC), and a microcontroller to have better sensing capabilities than a traditional Si NW discrete measuring system. In addition, an on-off key (OOK) wireless transceiver is also integrated to form a wireless bio-SSoC technology. This is pioneering work to harness the momentum of CMOS integrated technology into emerging bio-diagnosis technologies. This integrated technology is experimentally examined to have a label-free and low-concentration biomolecular detection for both Hepatitis B Virus DNA (10 fM) and cardiac troponin I protein (3.2 pM). Based on this work, the implemented wireless bio-SSoC has demonstrated a good biomolecular sensing characteristic and a potential for low-cost and mobile applications. As a consequence, this developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis.

Overview of CMOS image sensor use in molecular diagnostics

“…As such, cantileverbased fully integrated CMOS DNA diagnosis system-on-chip can be used to perform label-free DNA detection with high sensitivity. CMOS DNA cantilever sensor was embedded with a physical transducer of a polysilicon piezoresistor [74]. These compact, inexpensive, and high stability systems are known as a CMOS BioMicro electromechanical systems (CMOS Bio-MEMS) platform.…”

CMOS Circuits and Systems for Lab‐on‐a‐Chip Applications

“…In order to replace traditional optical inspection techniques, these techniques have been tested for the identification of objects at microscopic level to envision several applications [2].…”

Nanoscale virus biosensors: state of the art

“…127 Immunoamperometric techniques, using a commercial kit, were used to validate the accuracy of novel technology for virus concentration determination. 127 Huang et al 128 reported a polysilicon nanowire-based biosensor system-on-chip, fabricated by complementary metal-oxidesemiconductor (CMOS) process. In addition, an on-off key wireless transceiver was also integrated to form a wireless biosensor system-on-chip technology.…”

“…In addition, an on-off key wireless transceiver was also integrated to form a wireless biosensor system-on-chip technology. 128 This was a pioneering work to harness the momentum of CMOS-integrated technology into emerging biodiagnosis technologies, and examined to have label-free and low-concentration biomolecular detection, as a consequence. Such developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis.…”

“…Such developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis. 128 Fabrication of biocompatible nanofibrous materials by electrospinning was described by Luo et al 129 The novel nanostructure improves the biochemical binding effect and sensor signal-to-noise ratio. Luo et al 129 presented the electrospinning method of nitrocellulose nanofibrous membrane and its antibody functionalization for bovine viral diarrhea virus detection.…”