A CMOS capacitive dopamine sensor with Sub-nM detection resolution

Wang, Shiwei; Lin, Chih-Heng; Yang, Yuh‐Shyong; Lu, Michael S.-C.

doi:10.1109/icsens.2009.5398250

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…When a binding event occurs between the immobilized biological element (e.g., lectins, aptamers) and the analyte (e.g., hormones, DNA), changes in physical properties such as thickness, mass, or charge may be induced on the CMOS biosensors [13]. Hence, Using CMOS technology can be used to analyze DNA fragments of specific genes.…”

Section: Introductionmentioning

confidence: 99%

A CMOS-Based Capacitive Biosensor for Detection of a Breast Cancer MicroRNA Biomarker

Kuo

Chen

Huang

et al. 2020

IEEE Open J. Nanotechnol.

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Breast cancer ranks among the most common cancers worldwide and can be lethal when not diagnosed early due to the high probability of metastasis. Herein a complementary metal-oxide-semiconductor (CMOS)-based capacitive nano-biosensor was developed to quickly and accurately quantify the concentration of an early-stage breast cancer diagnostic marker, microRNA-195, in blood. The microRNA probe was immobilized on optimized inter-digitated electrodes (IDE), and CMOS-sensing circuits detected the probe-analyte reaction at microRNA-195 concentrations as low as 0.617 fM. This high sensitivity could be due to the monolithically integrated nature of the circuits, for which "parasitic" effects on the capacitive sensors were markedly low. The CMOS-based capacitive nano-sensor may be promising for early diagnosis of breast cancer.

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Section: Introductionmentioning

confidence: 99%

A CMOS-Based Capacitive Biosensor for Detection of a Breast Cancer MicroRNA Biomarker

Kuo

Chen

Huang

et al. 2020

IEEE Open J. Nanotechnol.

View full text Add to dashboard Cite

show abstract

“…from position measurement in the sub-nanometer range like in atomic force microscopy (e.g. [1]) over the detection of lowest concentrations of chemical substances in lab on chip systems ( [2]) to position measurement in the touch screens of mobile phones. For capacitive sensors, high precision measurement techniques have been developed over the past years.…”

Section: Introductionmentioning

confidence: 99%