A cluster of transfusion-associated babesiosis in extremely low birthweight premature infants

Kumar, Pratap; Marshall, Bruce C.; deBlois, G; Koch, William C.

doi:10.1038/jp.2012.33

Cited by 8 publications

(4 citation statements)

References 18 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although transfusions overall are increasingly safe, neonates, especially extremely preterm neonates, are particularly predisposed to transfusion complications, including acute reactions such as transfusion-associated circulatory overload (TACO) and transfusion-associated acute lung injury (TRALI) 6 , 7 , but are also quite vulnerable to short- and longer-term issues resulting from transfusion-transmitted diseases, such as Babesia and Zika virus 8 , 9 . The true incidence of adverse outcomes from transfusions in neonates is not known.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in transfusions in neonates/infants

Goel

Josephson

2018

F1000Res

View full text Add to dashboard Cite

Transfusions of red blood cells (RBCs), platelets, and plasma are critical therapies for infants and neonates (particularly preterm neonates) in the neonatal intensive care unit, who are the most frequently transfused subpopulation across all ages. Although traditionally a significant gap has existed between the blood utilization and the evidence base essential to adequately guide transfusion practices in infants and neonates, pediatric transfusion medicine is evolving from infancy and gradually coming of age. It is entering an exciting era with recognition as an independent discipline, a new and evolving high-quality evidence base for transfusion practices, novel technologies and therapeutics, and national/international collaborative research, educational, and clinical efforts. Triggers and thresholds for red cell transfusion are accumulating evidence with current phase III clinical trials. Ongoing trials and studies of platelet and plasma transfusions in neonates are anticipated to provide high-quality evidence in years to come. This article aims to summarize the most current evidence-based practices regarding blood component therapy in neonates. Data on the use of specific components (RBCs, plasma, and platelets) are provided. We attempt to define thresholds for anemia, thrombocytopenia, and abnormal coagulation profile in neonates to highlight the difficulties in having a specific cutoff value in neonates and preterm infants. Indications for transfusion of specific products, transfusion thresholds, and current practices and guidelines are provided, and possible adverse outcomes and complications are discussed. Finally, the critical research knowledge gaps in these practices as well as ongoing and future research areas are discussed. In an era of personalized medicine, neonatal transfusion decisions guided by a strong evidence base must be the overarching goal, and this underlies all of the strategic initiatives in pediatric and neonatal transfusion research highlighted in this article.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent advances in transfusions in neonates/infants

Goel

Josephson

2018

F1000Res

View full text Add to dashboard Cite

show abstract

“…8 Interestingly, many cases have been reported involving symptomatic neonates in the first month of life with presumed or proven congenital infection (ie, transplacental acquisition), [9][10][11][12][13][14][15][16][17][18] or with infection acquired from tick bites early in life. 19,20 Babesiosis has occurred in neonates [21][22][23][24][25][26][27][28] and immunocompromised children with congenital cardiac disease [29][30][31] because of transfusion of infected blood products. Clinical presentations similar to that of our patient have been reported in children with malignancies infected with E. chaffeensis and Ehrlichia ewingii.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, many cases have been reported involving symptomatic neonates in the first month of life with presumed or proven congenital infection (ie, transplacental acquisition),9–18 or with infection acquired from tick bites early in life 19,20. Babesiosis has occurred in neonates21–28 and immunocompromised children with congenital cardiac disease29–31 because of transfusion of infected blood products.…”

Section: Discussionmentioning

confidence: 99%

Do Not Forget About the Ticks: An Unusual Cause of Fever, GI Distress, and Cytopenias in a Child With ALL

Ungar¹,

Varkey

Pierro

et al. 2021

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

We report the case of a 5-year-old male with B-cell acute lymphoblastic leukemia in remission, receiving maintenance chemotherapy, who presented with fever, emesis, diarrhea, headache, and lethargy. He developed rapidly progressive cytopenias and was found to have acute human granulocytic anaplasmosis as well as evidence of past infection with Babesia microti. The case highlights the need to maintain a broad differential for infection in children undergoing chemotherapy or other immunosuppressive therapies with possible or known tick exposure.

show abstract

“…This is also due to fact that detecting the disease during this time is im-possible [55,60]. Blood-borne pathogens also include Cytomegalovirus (CMV) or protozoa of the genus Babesia [61][62][63]. Extravectorial babesiosis infection through blood products is not fully understood.…”

Section: Complications After Transfusion Of Blood and Blood Componentsmentioning

confidence: 99%

Use of blood and its components in the treatment of anaemia in children

Bernat

Jaworska-Lewtak

Kowalska-Kępczyńska

2022

Current Issues in Pharmacy and Medical Sciences

View full text Add to dashboard Cite

Blood transfusion is a well-established treatment for anaemia. Herein, blood and its components are transfused to replenish circulating blood volume, maintain the oxygen capacity of the blood and normalise the function of the coagulation system. Anaemia treatment by blood transfusions is a great challenge, especially with reference to paediatric patients. Blood is irreplaceable in a life-threatening situation, but it has its own side effects, just like all applied pharmacological products. Hence, it is extremely important to carefully select donors and utilise blood components according to the patient’s individual needs. Children represent a group that requires specific criteria to be met, mainly because of the fact that their physiological and haematological systems differ from those of adults. The most common types of anaemia seen in children are deficiency anaemias such as iron-deficiency anaemia, while less common are vitamin B12 deficiency anaemia or folate deficiency anaemia. Secondary anaemia is also relatively frequent in chronic diseases, among others, immunological or infectious, as well as renal, liver, endocrine and neoplastic diseases. Anaemia due to blood loss is also included in this group. Furthermore, some anaemias, such as aplastic anaemia (due to impaired erythrocyte production) and haemolytic anaemia (due to excessive destruction of red blood cells) may be congenital or acquired. Before deciding to implement blood therapy, the patient’s clinical condition or the different haematological, biochemical and immunological parameters at different stages of life should be considered. Since each transfusion may result in a variety of post-transfusion reactions, immunisation or transmission of infectious diseases, the decision to transfuse blood or blood components should be taken only when the patient cannot be treated effectively by any other means and the expected benefits of the transfusion outweigh the risks associated with possible complications. Considering the recipients’ low blood volume, low metabolic efficiency, higher haematocrit levels than in adults and immature immune system, products for these patients should be prepared in a special way. These components must ensure minimal risk of metabolic and haemostatic disorders. The collection of these products, as well as their preparation, storage and transfusion, should be carried out in accordance with current legislation.

show abstract

A cluster of transfusion-associated babesiosis in extremely low birthweight premature infants

Cited by 8 publications

References 18 publications

Recent advances in transfusions in neonates/infants

Recent advances in transfusions in neonates/infants

Do Not Forget About the Ticks: An Unusual Cause of Fever, GI Distress, and Cytopenias in a Child With ALL

Use of blood and its components in the treatment of anaemia in children

Contact Info

Product

Resources

About