A cluster of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup W among university students, France, February to May 2017

Bassi, Clément; Taha, Muhamed‐Kheir; Merle, Christian; Hong, Eva; Lévy-Brühl, Daniel; Barret, Anne-Sophie; Njoya, Ibrahim Mounchetrou

doi:10.2807/1560-7917.es.2017.22.28.30574

Cited by 23 publications

(17 citation statements)

References 20 publications

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“…The ST-11 complex (cc11) is associated with outbreaks with high CFRs, atypical symptoms (e.g. gastrointestinal findings) and a variety of serogroups (MenC, MenW, and MenB) [55][56][57][58]. The spread of cc11 has been accompanied by capsule switching and antigenic shifts, and more recently, adaptation to new niches, e.g.…”

Section: Genomic Alterations and Epidemic Potential Of Neisseria Menimentioning

confidence: 99%

“…MenW cc11 isolates found in the U.K. from 2009 onwards, and associated with atypical symptoms (diarrhea, vomiting, and septic arthritis), likely originated from South America, having emerged in Brazil in 2003 before spreading to Argentina and Chile [37,52,61]. The U.K. strains have since been found in France, the Netherlands, Sweden, Australia, and Canada [42,43,51,54,55,63]. Further, within the cc11 population structure, MenB and MenC cc11 isolates were highly interspersed, suggesting multiple capsule switch events [37,62].…”

Section: Genomic Alterations and Epidemic Potential Of Neisseria Menimentioning

confidence: 99%

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The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

Acevedo

Bai

Borrow

et al. 2018

Expert Review of Vaccines

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2019) The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and highrisk populations, Expert Review of Vaccines, 18:1, 15-30, ABSTRACT Introduction: The 2018 Global Meningococcal Initiative (GMI) meeting focused on evolving invasive meningococcal disease (IMD) epidemiology, surveillance, and protection strategies worldwide, with emphasis on emerging antibiotic resistance and protection of high-risk populations. The GMI is comprised of a multidisciplinary group of scientists and clinicians representing institutions from several continents. Areas covered: Given that the incidence and prevalence of IMD continually varies both geographically and temporally, and surveillance systems differ worldwide, the true burden of IMD remains unknown. Genomic alterations may increase the epidemic potential of meningococcal strains. Vaccination and (to a lesser extent) antimicrobial prophylaxis are the mainstays of IMD prevention. Experiences from across the globe advocate the use of conjugate vaccines, with promising evidence growing for protein vaccines. Multivalent vaccines can broaden protection against IMD. Application of protection strategies to high-risk groups, including individuals with asplenia, complement deficiencies and human immunodeficiency virus, laboratory workers, persons receiving eculizumab, and men who have sex with men, as well as attendees at mass gatherings, may prevent outbreaks. There was, however, evidence that reduced susceptibility to antibiotics was increasing worldwide. Expert commentary: The current GMI global recommendations were reinforced, with several other global initiatives underway to support IMD protection and prevention. ARTICLE HISTORY

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Section: Genomic Alterations and Epidemic Potential Of Neisseria Menimentioning

confidence: 99%

Section: Genomic Alterations and Epidemic Potential Of Neisseria Menimentioning

confidence: 99%

The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

Acevedo

Bai

Borrow

et al. 2018

Expert Review of Vaccines

Self Cite

145

166

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“…The sub-lineage consists of three strains: the South American strain, the original UK strain, and the UK 2013 strain (hereafter called the 2013 strain) [13,14]. An increase in NmW has been reported from several European countries [14][15][16][17], and in 2015, the 2013 strain was involved in an outbreak at an international scout jamboree in Japan, which resulted in invasive cases reported from Scotland and Sweden [13].…”

Section: Introductionmentioning

confidence: 99%

Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice

et al. 2020

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Background: Neisseria meningitidis serogroups W and Y are the most common serogroups causing invasive meningococcal disease in Sweden. The majority of cases are caused by the serogroup W UK 2013 strain of clonal complex (cc) 11, and subtype 1 of the serogroup Y, YI strain of cc23. In this study, virulence factors of several lineages within cc11 and cc23 were investigated in transgenic BALB/c mice expressing human transferrin. Transgenic mice were infected intraperitoneally with serogroup W and Y isolates. Levels of bacteria and the proinflammatory cytokine CXCL1 were determined in blood collected 3 h and 24 h post-infection. Apoptosis was investigated in immune cells from peritoneal washes of infected mice. Adhesion and induction of apoptosis in human epithelial cells were also scored. Results: The levels of bacteraemia, CXCL1, and apoptosis were higher in serogroup W infected mice than in serogroup Y infected mice. Serogroup W isolates also induced higher levels of apoptosis and adhesion in human epithelial cells. No significant differences were observed between different lineages within cc11 and cc23. Conclusions: N. meningitidis Serogroup W displayed a higher virulence in vivo in transgenic mice, compared to serogroup Y. This was reflected by higher bacteremia, proinflammatory activity, and ability to induce apoptosis in mouse immune cells and human epithelial cells.

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“…The study of these isolates by the whole genome sequencing (WGS) method revealed two genetically close lineages: one is linked to the Hajj 2000 epidemic and its subsequent spread throughout the world, including to South Africa, and the other is recently reported from Latin America, England, and other countries. The European isolates serogroup W cc11 of the latter lineage are classified into two sub-lineages: original UK strain and novel 2013 UK strain [4, 5, 6, 7, 8, 9, 10]. In 2015-2016, the resurgence of N. meningitidis W cc11 was reported in Madagascar.…”

Section: Introductionmentioning

confidence: 99%

Whole genome sequencing of Neisseria meningitidis W isolates from the Czech Republic recovered in 1984 – 2017

Honskus¹,

Okonji²,

Musílek³

et al. 2018

Preprint

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A cluster of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup W among university students, France, February to May 2017

Cited by 23 publications

References 20 publications

The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice

Whole genome sequencing of Neisseria meningitidis W isolates from the Czech Republic recovered in 1984 – 2017

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