A cluster of HTLV-1 associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution.

Kayembe, K; Goubau, Patrick; Desmyter, Jan; Vlietinck, Robert; Carton, Herwig

doi:10.1136/jnnp.53.1.4

Cited by 78 publications

(37 citation statements)

References 29 publications

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“…If this concept is correct TSP should begin to appear in UK-bom subjects, provided viral transmission occurs in this temperate area, but it may take decades to become apparent given the inefficiency of acquisition. Host factors may also be important in determining whether a patient of Afro-Caribbean origin develops MS or a white European presents with TSP but data presented here, and those of Dean, [1][2][3][4][5][6] suggest that, as far as MS is concerned, environmental factors predominate over ethnic ones.…”

Section: Discussionmentioning

confidence: 98%

Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom.

Rudge

Amini

Cruickshank

1991

Journal of Neurology, Neurosurgery & Psychiatry

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Forty four consecutive patients of AfroCaribbean origin resident in the United Kingdom (UK) were studied, based on a provisional diagnosis of myelopathy of unknown cause, tropical spastic paraparesis (TSP) or multiple sclerosis (MS). Of 30 patients with progressive paraparesis 27 had serum antibodies to HTLV-1 and were classified as having TSP. Fourteen patients fulfilled the criteria for MS and none of 12 tested had HTLV-1 antibodies. All the TSP patients and nine of those with MS were born in the West Indies. Five of the West Indianborn MS patients had migrated to the UK after adolescence but the duration of residence in the UK before symptoms of MS developed was similar to those born in the UK (average 18 years). The features that differentiated MS from TSP patients, apart from HTLV-1 status, included clinical evidence of cranial nerve involvement, more extensive abnormalities on the brain and cervical cord MRI and asymmetry of the VEP latency increase, all of which were more frequent in the MS group. Of the three patients without a diagnosis one, born in the UK, had marked abnormalities on MRI of the brain indistinguishable from those seen in MS.

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Section: Discussionmentioning

confidence: 98%

Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom.

Rudge

Amini

Cruickshank

1991

Journal of Neurology, Neurosurgery & Psychiatry

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“…42 On the other hand, the Pityrosporum yeasts, which frequently occur in SD, 43 Although HAM/TSP is considered a pathology of adults, there are 17 well-documented cases in the literature of HAM/TSP diagnosed in children and adolescents, 13 of which were described in Brazil. 47,49,[55][56][57][58][59][60][61] In these cases a predominance of the female sex was observed. In contrast with the adult form of the disease, in the juvenile form of HAM/TSP infection is acquired vertically.…”

Section: Differential Clinical Diagnosismentioning

confidence: 99%

Manifestações infanto-juvenis da infecção pelo vírus linfotrópico de células T humanas (HTLV-I)

Bittencourt¹,

Primo²,

Oliveira³

2006

J. Pediatr. (Rio J.)

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Objectives: To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment.Sources: Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search databases were: HTLV-I-associated infective dermatitis, HTLV-Iassociated myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, HTLV-I-associated uveitis.Summary of the findings: IDH is a chronic, relapsing and infected dermatitis of childhood which always involves the scalp and which may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children and adolescents in the literature, 12 of whom are patients with IDH. In contrast with the adult form of the disease, the juvenile form is rapid and progressive. ATL is a type of Tcell leukemia/lymphoma that affects adults and is generally fatal. Eleven of the 24 published reports of ATL in children and adolescents were diagnosed in Brazil.Conclusions: These diseases are likely to be more common in childhood and adolescence than the literature would suggest. It is advisable that serological testing be performed for HTLV-I in children and adolescents suffering from chronic and relapsing eczema, with signs and symptoms of myelopathy or with a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know how to recognize the pediatric manifestations of this infection in order to correctly diagnose them and offer their patients appropriate guidance and treatment.

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“…Thus, the prevaIence of TSPIHAM ranges from 8.6/100000 inhabitants in Kyushu (Japan) (Shibasaki et al, 1989;Kaplan et al, 1990;Osame et al, 1990) to 128/100000 in Mahé (Seychelles) (Gessain & Gout, 1992). Estimates of the annual incidence range from 0.04/100000 in Kyushu (Shibasaki et al, 1989;Kaplan et al, 1990) to 3/100000 in Lisala (Zaire) (Kayembe et al, 1990). The femaIe predominance seems to be less marked in South America (Araújo et aL., 1993), where TSPIHAM affects aH racial groups (Araújo et aL., 1993;Rodgers-Johnson, 1994;Domingues et aL., 1995).…”

Section: +mentioning

confidence: 99%

“…The prevaIence of TSPIHAM varies greatly across geographical areas despite similar leveIs of HTL V-I seropositivity (Román et aL., 1987;Kaplan et al, 1990;Kayembe et al, 1990;Trujilo et al, 1992;Jeannel et al, 1993). Thus, southern Japan and…”

Section: +mentioning

confidence: 99%

“…TSP/HAM is more frequent in women (sex ratio ranging from i : 1.5 in Japan i : 3.5 in Martinique) and is common in most HTL V -L endemic areas, but is very rare in children (Osame et al, I986a;Román et al, 1987;Shibasaki et al, 1989;Kaplan et aL., 1990;Kayembe et aL., 1990;Janssen et al, 1991;Ramiandrisoa et al, 1991;Gessain & Gout, 1992;Jeannel et aL., 1993), where it can be one of the major neurological diseases. Reliable estimates of TSPIHAM incidence and prevaIence are available only for Japan, sorne Caribbean areas and rare clusters in Africa and South America (Gessain & Gout, 1992).…”

Section: +mentioning

confidence: 99%

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Monographs on the Evaluation of Carcinogenic Risks to Humans

1991

Analytica Chimica Acta

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A cluster of HTLV-1 associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution.

Cited by 78 publications

References 29 publications

Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom.

Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom.

Manifestações infanto-juvenis da infecção pelo vírus linfotrópico de células T humanas (HTLV-I)

Monographs on the Evaluation of Carcinogenic Risks to Humans

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