A Cluster of Cases of Thyroid Hyperplasia in Aquarium-Housed Tropical Marine Teleosts Following a Change of Salt Mix Brand

Jalenques, Marion; Vergneau‐Grosset, Claire; Summa, Noémie; Youcef, Wahiba Ait; St-Cyr, Jean-Francois; Lair, Stéphane

doi:10.1638/2019-0221

Cited by 2 publications

(1 citation statement)

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“…These include exposure to goitrogenic substances (endosulfan, malathion, carbamate pesticides, cyanide compounds, trihalomethanes, ammonia, perchlorate) and deficiencies of iodine within the diet and/or the environment. 5,9 As a result, serum thyrotropin increases to abnormal levels, causing stimulation of the thyroid follicles and resulting in proliferation and hyperplasia. Although teleost endocrinology is poorly understood, elevation in the risk of developing thyroid carcinoma as a result of higher serum thyrotropin is well documented in human clinical endocrinology and oncology.…”

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Thyroid neoplasia associated with nutritional deficiency in cultured jade perch in Hong Kong

Chan,

Lim,

Leung

et al. 2024

J VET Diagn Invest

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Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We diagnosed cases of thyroid neoplasia in a population of jade perch ( Scortum barcoo). The 3,000 affected fish had grossly apparent, bilateral pharyngeal swellings. Histologic examination confirmed proliferative thyroid lesions ranging from hyperplasia to well-differentiated follicular cell carcinoma. In addition, the younger population of animals on the farm also had bacterial septicemia and mild Dactylogyrus sp. gill infections. Feed analysis revealed a severe deficiency of iodine and vitamin C in the homemade fish diet used on the farm. The concentrations of other minerals, such as zinc, were also on the lower end of the recommended requirements for freshwater fish. The farm was using surface water in its recirculating aquaculture system. We recommended a switch to a commercial aquaculture diet, as well as to use well water rather than surface water to avoid any contaminants, and to treat the younger fish with an antibiotic for bacterial septicemia. Our case provides evidence of progression from nutritional-associated thyroid hyperplasia to neoplasia in farmed teleost fish.

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