A Clostridium hathewayi isolate in blood culture of a patient with an acute appendicitis

Randazzo, Adrien; Kornreich, Anne; Lissoir, Bénédicte

doi:10.1016/j.anaerobe.2015.07.003

Cited by 23 publications

(16 citation statements)

References 21 publications

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“…Among these MGS changing post-RYGB, H. hathewayi (a Clostridiales member of the phylum Firmicutes) was associated with improved trunk-fat mass and HbA1c. This species has not previously been linked to metabolic diseases, but is associated with sepsis, where it is increased in the blood 55 . Alistipes shahii increased post-BS and was associated with metabolic improvements confirming previous data 50.…”

Section: Discussionmentioning

confidence: 99%

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

Aron‐Wisnewsky

Prifti

Belda

et al. 2018

Gut

325

262

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Section: Discussionmentioning

confidence: 99%

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

Aron‐Wisnewsky

Prifti

Belda

et al. 2018

Gut

325

262

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“…Enrichment of E. faecalis levels in CF children has previously been shown 18 . The antibiotic resistance of E. faecalis is widely recognised and has received considerable attention as one of the major threats to human health as a consequence 26 – 28 , while C. hatewayi has also been linked to human bacteremia and infections 29 , 30 . Detecting increased abundances of resistance pathways/genes in these bacteria in the CF gut is unsurprising, but of concern, and likely reflects the chronic exposure to antibiotics and their effects on gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

A pilot study demonstrating the altered gut microbiota functionality in stable adults with Cystic Fibrosis

Fouhy

Ronan

O’Sullivan

et al. 2017

Sci Rep

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Cystic Fibrosis (CF) and its treatment result in an altered gut microbiota composition compared to non-CF controls. However, the impact of this on gut microbiota functionality has not been extensively characterised. Our aim was to conduct a proof-of-principle study to investigate if measurable changes in gut microbiota functionality occur in adult CF patients compared to controls. Metagenomic DNA was extracted from faecal samples from six CF patients and six non-CF controls and shotgun metagenomic sequencing was performed on the MiSeq platform. Metabolomic analysis using gas chromatography-mass spectrometry was conducted on faecal water. The gut microbiota of the CF group was significantly different compared to the non-CF controls, with significantly increased Firmicutes and decreased Bacteroidetes. Functionality was altered, with higher pathway abundances and gene families involved in lipid (e.g. PWY 6284 unsaturated fatty acid biosynthesis (p = 0.016)) and xenobiotic metabolism (e.g. PWY-5430 meta-cleavage pathway of aromatic compounds (p = 0.004)) in CF patients compared to the controls. Significant differences in metabolites occurred between the two groups. This proof-of-principle study demonstrates that measurable changes in gut microbiota functionality occur in CF patients compared to controls. Larger studies are thus needed to interrogate this further.

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“…This is in accordance with Jørgensen et al (45), who observed the enrichment of genus Hungatella in 16S rRNA microbiome of CVID patients. H. hathewayi is a part of the normal human intestinal microflora (44,46,47), but it is also involved in various human infections (48)(49)(50), and its abundance was increased among patients suffering from cystic fibrosis (51), primary IgA nephropathy (52), chronic kidney disease (53), and colon cancer (54)(55)(56).…”

Section: Cvid Microbiota Shows Subtle Differences On a Species Levelmentioning

confidence: 99%

Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates

Bosák¹,

Lexa²,

Fiedorová³

et al. 2021

Front. Immunol.

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Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous disorder with inadequate antibody responses and low levels of immunoglobulins including IgA that is involved in the maintenance of the intestinal homeostasis. In this study, we analyzed the taxonomical and functional metagenome of the fecal microbiota and stool metabolome in a cohort of six CVID patients without gastroenterological symptomatology and their healthy housemates. The fecal microbiome of CVID patients contained higher numbers of bacterial species and altered abundance of thirty-four species. Hungatella hathewayi was frequent in CVID microbiome and absent in controls. Moreover, the CVID metagenome was enriched for low-abundance genes likely encoding nonessential functions, such as bacterial motility and metabolism of aromatic compounds. Metabolomics revealed dysregulation in several metabolic pathways, mostly associated with decreased levels of adenosine in CVID patients. Identified features have been consistently associated with CVID diagnosis across the patients with various immunological characteristics, length of treatment, and age. Taken together, this initial study revealed expansion of bacterial diversity in the host immunodeficient conditions and suggested several bacterial species and metabolites, which have potential to be diagnostic and/or prognostic CVID markers in the future.

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A Clostridium hathewayi isolate in blood culture of a patient with an acute appendicitis

Cited by 23 publications

References 21 publications

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

A pilot study demonstrating the altered gut microbiota functionality in stable adults with Cystic Fibrosis

Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates

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