A closer look at pathogenesis of cerebral mucormycosis in diabetic condition: A mini review

Khoshbayan, Amin; Didehdar, Mojtaba; Chegini, Zahra; Taheri, Forough; Shariati, Aref

doi:10.1002/jobm.202000692

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Spreading through disrupted cutaneous barriers, following major trauma, represents a major route of infection in immunocompetent hosts [ 4 , 15 , 16 , 17 , 18 ]. In addition to the huge number of spores present in soil-contaminated wounds, acidosis due to large soft tissue damage and a lack of tissue viability associated with local immunodepression could explain the pathogenicity of Mucorales after injury [ 4 , 15 , 18 ]. It is also of note that major trauma has been shown to cause a systemic immunocompromised state [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated Cerebral Mucormycosis Caused by Lichtheimia Species in a Polytrauma Patient

et al. 2022

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Isolated post-traumatic cerebral mucormycosis represents an extremely rare and severe disease. A case of isolated cerebral mucormycosis infection caused by Lichtheimia spp. in a 21-year-old multi-trauma patient is presented. The patient was hospitalized in the intensive care unit and underwent craniotomy due to brain injuries. Two weeks following the initial procedure, pus drained from the surgical wound was microscopically examined and cultured, yielding Lichtheimia spp. Imaging showed parietal, temporal and frontal abscesses at the right side. The patient was commenced on amphotericin B and underwent surgical debridement, while histopathological examination of the affected tissue demonstrated broad, aseptate hyphae, findings typical for mucormycetes. The patient passed away due to heavy traumatic injuries after 2 months. It is speculated that direct inoculation was the portal of entry for infection, and that high steroid use for 2 weeks following inoculation contributed to the severity of infection that developed. Isolated cerebral mucormycosis in immunocompetent hosts is an extremely rare, but severe disease. Diagnosis is established through direct microscopy, histopathology and/or cultures. PCR-based techniques are useful either to detect mucormycetes in tissues, especially when cultures are negative, or to accurately identify the fungi grown in cultures at the species level. A high suspicion index, especially in the necrotic lesions of traumas, is of the utmost importance for early diagnosis. Appropriate surgical debridement, as well as antifungal therapy, including amphotericin B, represents the treatment of choice.

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Section: Discussionmentioning

confidence: 99%

Isolated Cerebral Mucormycosis Caused by Lichtheimia Species in a Polytrauma Patient

et al. 2022

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The causal relationship between autoimmune diseases and rhinosinusitis, and the mediating role of inflammatory proteins: a Mendelian randomization study

Liang,

Yin,

Chen

et al. 2024

Exp. Biol. Med.

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Observational studies have linked autoimmune diseases (ADs) with rhinosinusitis (RS) manifestations. To establish a causal relationship between ADs and RS, and to explore the potential mediating role of inflammatory mediators between ADs and RS, we utilized Mendelian randomization (MR) analysis. Using a two-sample MR methodology, we examined the causality between multiple sclerosis (MS), rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriasis (PsO), type 1 diabetes (T1D), Sjogren’s syndrome (SS), celiac disease (CeD), Crohn’s disease (CD), hypothyroidism (HT), Graves’ disease (GD), and Hashimoto’s thyroiditis and their association with chronic and acute rhinosinusitis (CRS and ARS, respectively).To achieve this, we employed three distinct MR techniques: inverse variance weighting (IVW), MR-Egger, and the weighted median method. Our analysis also included a variety of sensitivity assessments, such as Cochran’s Q test, leave-one-out analysis, MR-Egger intercept, and MR-PRESSO, to ensure the robustness of our findings. Additionally, the study explored the role of inflammation proteins as a mediator in these relationships through a comprehensive two-step MR analysis. Among the ADs, MS, RA, T1D, CeD, and HT were determined as risk factors for CRS. Only CeD exhibited a causal relationship with ARS. Subsequent analyses identified interleukin-10 (IL-10) as a potential mediator for the association of MS, RA and HT with CRS, respectively., while C-X-C motif chemokine 10 levels (CXCL10) and T-cell surface glycoprotein CD6 isoform levels (CD6) were found to influence HT’s effect on CRS. Our findings demonstrate a causative link between specific autoimmune diseases and rhinosinusitis, highlighting IL-10, CXCL10, and CD6 as potential mediators in this association.

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A closer look at pathogenesis of cerebral mucormycosis in diabetic condition: A mini review

Cited by 2 publications

References 47 publications

Isolated Cerebral Mucormycosis Caused by Lichtheimia Species in a Polytrauma Patient

Isolated Cerebral Mucormycosis Caused by Lichtheimia Species in a Polytrauma Patient

The causal relationship between autoimmune diseases and rhinosinusitis, and the mediating role of inflammatory proteins: a Mendelian randomization study

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