A closer look at NIFTP

Dhanushika, T; Priyani, A. A. H.; Ranaweera, Melanie; Ranaweera, Gayani; Silva, M V C de; Dassanayake, R.S.

doi:10.1007/s42000-020-00206-w

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Therefore, based on their low-risk molecular profile and indolent biological behaviour, they should be distinguished from infiltrative FVPTCs [ 5 , 10 ]. To reduce clinical overtreatment and psychological consequences associated with a diagnosis of “cancer”, non-invasive encapsulated FVPTCs have been reclassified as NIFTPs [ 1 ], with the goal to denote a group of follicular neoplasm with an indolent behaviour [ 11 ]. The diagnosis of NIFTP is only possible after surgical excision of the nodule, because the tumour capsule must be entirely inspected to exclude invasion foci.…”

Section: Introductionmentioning

confidence: 99%

Clinical-Pathological and Molecular Evaluation of 451 NIFTP Patients from a Single Referral Center

Vignali

Proietti

Macerola

et al. 2022

Cancers

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Background: Non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs) were introduced in thyroid pathology in 2016. NIFTPs are a group of follicular neoplasm with an indolent behaviour. In this study, we gathered a large retrospective cohort of NIFTPs and compared those presenting as solitary lesions and NIFTPs found in multifocal setting. Methods: A retrospective search of NIFTPs was performed, and the clinico-pathological features were recorded. For a subgroup of patients, pre-surgical ultrasound (US) evaluation, cytological diagnosis, and molecular analysis were available. Results: We collected 451 NIFTPs; 254 (56.3%) were truly solitary tumours, while 197 coexisted with one or more NIFTP/cancer. Contrasting unifocal and multifocal settings, NIFTPs size was the only significantly different parameter. Preoperatively, NIFTP nodules mostly showed low-risk US characteristics, indeterminate cytology and a RAS-like molecular profile. Conclusion: NIFTPs often coexist with collateral thyroid tumours. However, no clinical-pathological differences can be observed between solitary and “multifocal” NIFTPs. Despite the well-established clinical indolence of NIFTP, a careful monitoring of the contralateral lobe should not be excluded.

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