A close-up on doxorubicin binding to γ-cyclodextrin: an elucidating spectroscopic, photophysical and conformational study

Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface

“…It has been reported (Agrawal et al, 2009;Anand et al, 2012;Fulop et al, 2013;Hayakawa et al, 1991;Li et al, 1998;Porumb, 1978;Rizzo et al, 1989) that Dox tends to self-assemble in aqueous solutions forming dimers or higher order oligomers. The extent of agglomeration is highly sensitive to concentration of drug macromolecules, acidity of solution, and presence of additives (Anand et al, 2012;Hayakawa et al, 1991;Porumb, 1978). Self-assembling of Dox molecules leads to the changes in the relative intensities of absorption peaks in the visible region of spectra ( Figure 9).…”

Synthesis and Inclusion Study of a Novel γ-Cyclodextrin Derivative as a Potential Thermo-Sensitive Carrier for Doxorubicin

“…6, a good liner relationship between the fluorescence intensity of DOX in the 39) for the native γ-CD with DOX in 1 : 1 complex formation. The high value of K binding of our modified 3b can be attributed to the modification by the naphthalene group, which potentially exhibits π-π interaction between the aromatic rings in 3b and DOX molecules as suggested by the NMR studies.…”

Facile preparation of cyclodextrin-grafted chitosans and their conversion into nanoparticles for an anticancer drug delivery system

“…The structure of the β-CyD-g-CS was confirmed by 1 H NMR analysis (Figure 1c), revealing signals attributed to protons of residual acetyl groups in a CS (g), the 2-position of unreacted-glucosamine units in CS (f), a methylene in carboxymethyl moiety (e), most of the sugar protons in CS and CyD residues (sugar protons), anomeric protons of CS (d, c) and β-CyD residues (a, a' and b). In addition, 13 C NMR, IR and elemental analyses (see the experimental section) also supported the production of β-CyD-g-CS. The β-CyD content, which is the molar ratio of the CyD-bearing glucosamine unit in the β-CyDg-CS, was estimated from the integrated ratio of anomeric protons of CS (c and d) and the β-CyD residues (a, a' and b) to be 9.6%.…”

“…[5][6][7][8] A facile method with shorter steps and an easier procedure would accelerate the further application and functionalization of CyD-g-CS. Besides, both CS 9-12 and CyD derivatives [13][14][15] are known as candidate materials for anticancer drug delivery systems. Thereby, CyD-g-CSs, which are conjugates of both candidates, and their derivatives would provide improved anticancer drug delivery systems showing enhanced binding of a drug as well as improved therapeutic efficacy.…”