A Clinocopathological Study of Gastrointestinal Stromal Tumor (Gist) Located in the Stomach and Small Intestine

Kusanagi, Hiroshi; Sugimoto, T.; Naito, Noritugu; Sugimura, Yukiharu; Endo, Satoshi; Ohta, Takao; Yamada, Shigetoshi; Mike, Makio; Kano, Nobuyasu; Narita, Makoto

doi:10.3919/jjsa.70.3229

Cited by 2 publications

(1 citation statement)

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“…According to the review of 4813 symptomatic GIST, the frequency of coexisting malignant tumor was 10.1% and that of gastric cancer was about 2% [ 10 ]. The Japanese study of 109 GIST cases reported that 21.3% had malignant tumors and only 1 case (0.9%) had gastric cancer [ 15 ]. Because the prevalence of gastric cancer is 102/1,00,000/year [ 16 ] in Japan, the coexistence rate of gastric cancer with gastric GIST in 0.9–2% may mean that it occurs more frequently than coincidence.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of gastric cancer and gastric GIST with intra-tumor bleeding: successful embolization with subsequent total gastrectomy

et al. 2021

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Background Gastrointestinal stromal tumor (GIST) is a rare tumor, however, simultaneous development of gastric cancer and gastric GIST has been documented more frequently in recent years. Rupture of gastric GIST is even more rare and occurred in 7% of all GISTs. Although ruptured GIST might be occasionally difficult to be managed by endoscopy, transcatheter arterial embolization (TAE) was reported to control bleeding from GIST effectively. We report herein a case of coexistence of gastric cancer and gastric GIST with progressing intra-tumor bleeding managed successfully by TAE and review the clinicopathological characteristics of this rare condition reported previously in the Japanese literature. Case presentation A 75-year-old woman with dyspnea and systemic edema was diagnosed as simultaneous occurrence of gastric cancer (histopathologically detected tubular adenocarcinoma pT2N1M0 fStageIIA) and gastric GIST (65 × 92 mm in diameter at the anterior wall of the fornix) with intra-tumor hemorrhage. Perceiving the progress of bleeding from tumor growth and exacerbating anemia, TAE of left gastric artery was performed. Then remission of anemia has been obtained, the patient underwent an elective radical surgery. Conclusions Simultaneous occurrence of gastric cancer and gastric GIST was speculated to be more common. TAE for ruptured GIST may be effective for hemostasis and reduction of tumor burden, which could facilitate minimal invasive surgery.

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Section: Discussionmentioning

confidence: 99%