A clinicoradiographic assessment of 1% metformin gel with platelet-rich fibrin in the treatment of mandibular grade II furcation defects

Sharma, Parul; Grover, Harpreet Singh; Masamatti, Sujata Surendra; Saksena, Neha

doi:10.4103/jisp.jisp_292_17

Cited by 9 publications

(16 citation statements)

References 32 publications

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“…Greater attachment levels and bone-fill were notable findings. Similar improvements in patient outcomes were observed for mandibular Grade II furcation defects [74] and gingival recession defects [75,76,77,78,79,80,81]. Its ability to relieve pain and post-operative swelling during tooth extractions and in the treatment of tooth lesions, are also widely documented [82,83,84,85,86,87,88,89,90,91,92].…”

Section: Methods—literature Reviewmentioning

confidence: 61%

Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

et al. 2019

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New therapies that accelerate musculoskeletal tissue recovery are highly desirable. Platelet-rich fibrin (PRF) is a leukocyte- and platelet-rich fibrin biomaterial that acts as a binding site for both platelets and growth factors. Through increasing the local concentration of growth factors at specific tissues, PRF promotes tissue regeneration. PRF has been frequently used in combination with bone graft materials to reduce healing times and promote bone regeneration during maxillofacial surgery. However, its benefits during muscle repair and recovery are less well-documented. Here, we perform a narrative review on PRF therapies and muscle injuries to ascertain its beneficial effects. We reviewed the factors that contribute to the biological activity of PRF and the published pre-clinical and clinical evidence to support its emerging use in musculoskeletal therapy. We include in vitro studies, in vivo animal studies and clinical articles highlighting both the success and failures of PRF treatment. PRF can promote the healing process when used in a range of orthopaedic and sports-related injuries. These include cartilage repair, rotator cuff surgery and anterior cruciate ligament surgery. However, conflicting data for these benefits have been reported, most likely due to inconsistencies in both PRF preparation protocols and dosing regimens. Despite this, the literature generally supports the use of PRF as a beneficial adjuvant for a range of chronic muscle, tendon, bone or other soft tissue injuries. Further clinical trials to confirm these benefits require consistency in PRF preparation and the classification of a successful clinical outcome to fully harness its potential.

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Section: Methods—literature Reviewmentioning

confidence: 61%

Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

et al. 2019

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“…A similar study was performed Taneja et.al, comparing the differences between PRF/MFT and PRF at 6 and 9 months [82]. A study was also found evaluating the possible use of OFD/PRF/MFT in the treatment of grade II mandibular furcation defects [81]. It has been shown that biguanide drugs in combination with PRF is widely used in periodontal therapy, which indicates the ability of PRF to be a drug delivery vehicle.…”

Section: Biguanidesmentioning

confidence: 79%

From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

Egle

Šalma

Dubņika

2021

IJMS

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The purpose of this review is to examine the latest literature on the use of autologous platelet-rich fibrin as a drug and growth factor carrier system in maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system that combines properties such as biocompatibility and biodegradability, in addition to containing growth factors and peptides that provide tissue regeneration. This opens up new horizons for the use of all beneficial ingredients in the blood sample for biomedical purposes. By itself, PRF has an unstable effect on osteogenesis: therefore, advanced approaches, including the combination of PRF with materials or drugs, are of great interest in clinics. The main advantage of drug delivery systems is that by controlling drug release, high drug concentrations locally and fewer side effects within other tissue can be achieved. This is especially important in tissues with limited blood supply, such as bone tissue compared to soft tissue. The ability of PRF to degrade naturally is considered an advantage for its use as a “warehouse” of controlled drug release systems. We are focusing on this concentrate, as it is easy to use in manipulations and can be delivered directly to the surgical site. The target audience for this review are researchers and medical doctors who are involved in the development and research of PRFs further studies. Likewise, surgeons who use PRF in their work to treat patients and who advice patients to take the medicine orally.

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“…Three studies evaluated the treatment outcomes of L-PRF besides OFD compared with OFD alone. 22,78,79 In four studies, L-PRF was applied mixed with other materials including metformin gel, 80 bioactive ceramic composite granules (BCCG), 81 rosuvastatin, 82 hydroxyapatite (HA), 82 and alendronate. 83 Asimuddin et al 84 compared the effect of PRF alone with allograft and healiguide collagen membrane.…”

Section: Management Of Furcation Defectsmentioning

confidence: 99%

“…Siddiqui et al 79 suggested that using β-tricalcium phosphate (β-TCP) lead to better treatment outcomes when compared with PRF. It was shown that when PRF applied mixed with rosuvastatin and HA, 82 alendronate, 83 and metformin, 80 the treatment outcome improved when compared with PRF alone. Furthermore, Lohi et al 81 reported that supplemental use of PRF besides BCCG led to significant improvements in all measured parameters.…”

Section: Management Of Furcation Defectsmentioning

confidence: 99%

“…Platelet-rich fibrin concentrates showed a significant effect on the improvement of clinical and radiographic parameters when used as an adjunctive treatment or sole treatment for furcation involvement of mandibular molars. 22,[78][79][80][81][82][83][84] However, when PRF was used as alternative material compared with β-TCP, it showed a significant advantage in PPD reducitions, CAL gains and bone filling. 79 In case of the root coverage of Miller class I and II defects, significant enhancement of root coverage procedures was not observed when PRF concentrates were applied.…”

Section: Reviewmentioning

confidence: 99%

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Application of Platelet Rich Fibrin in the Regeneration of Intra Oral Defects: A Systematic Review

Al-Shuhayeb

Meymandi

Ardakani

et al. 2019

J. Contemp. Med. Sci.

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Objective: To systematically review the randomized clinical trials (RCTs) on the effect of Platelet Rich Fibrin (PRF) concentrate on the tissue regeneration of intra-oral defects. Methods: An electronic search was performed in PubMed/Medline and Cochrane Library using relevant keywords until June 2018. RCTs which used PRF concentrate for treatment of intrabony defects, sinus augmentation, furcation involvement, endo-periodontal lesions, gingival recession, and ridge preservation were included in the present review. Results: In total, 79 studies that were used PRF either solely or mixed in human trials were included and divided based on the defect type. Most of the studies used PRF to treat intra-bony defects showed that it would improve treatment outcomes. In case of furcation involvement, the application of L-PRF in addition to open flap debridement improved the bone regeneration in grade II mandibular furcation involvement. In case of ridge preservation and sinus floor augmentation, the results were controversial. Conclusions: The result of the current systematic review implied that the treatment outcome of PRF application for periodontal and soft tissue repair depends on the treatment strategies and type of the defect. It was shown to PRF application is a practical approach to accelerate and enhance new bone formation in human studies in intrabony defects and furcation involvements. However, further clinical trials for evaluation of other types of intra-oral defects are required.

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A clinicoradiographic assessment of 1% metformin gel with platelet-rich fibrin in the treatment of mandibular grade II furcation defects

Cited by 9 publications

References 32 publications

Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

Application of Platelet Rich Fibrin in the Regeneration of Intra Oral Defects: A Systematic Review

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