A clinicopathological study of scarring alopecia

Nayar, M. S. B.; Schomberg, K.; Dawber, R.P.R.; Millard, P.R.

doi:10.1111/j.1365-2133.1993.tb00230.x

Cited by 46 publications

(44 citation statements)

References 12 publications

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“…PB can be considered either the final atrophic stage of several scarring disorders such as lichen planus pilaris (LPP) and discoid lupus erythematosus (DLE) (secondary PB) or an autonomous disease (primary PB). PB is a type of scarring alopecia of the scalp associated with a peculiar clinical presentation and evolution, which cannot be considered an autonomous nosologic entity because in 66.6% of patients it is the end stage of other inflammatory chronic diseases such as LPP and DLE [9]. The early evolving lesions of the hair follicles are described in pseudopelade, a type of cicatricial alopecia where clues for the diagnosis of lupus erythematosus or lichen plano-pilaris are lacking.…”

Section: Discussionmentioning

confidence: 99%

A clinical and histopathological study of cicatricial alopecia

Puri¹,

Puri²

2013

Our Dermatol Online

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Introduction: Cicatrical alopecia occurs in otherwise healthy men and women of all ages and is seen worldwide Material and Methods: A study of 40 patients was conducted to study the clinical variants and histopathology of cicatricial alopecia. Results and Discussion: n our study, it was seen that maximum number of cases of cicatrical alopecia were of LPP (27.5%) followed by 25% of DLE, 20% patients had pseudopelade of Brocq, SLE was seen in 5% cases followed by Scleroderma, dermatomyositis, Keratosis follicularis spinulosa decalvans, aplasia cutis, kerion, follicular mucinosis, pemphigus, dissecting cellulitis of scalp/ pyogenic folliculitis and acne keloidalis nuchae in 2.5% cases each. Regarding the morphology of lesions,epidermal atrophy was seen in 90% patients, erythema was seen in 55% cases, follicular pluging was seen in 40% patients, telangiectasias in 27.5% patients, diffuse scaling in 25% patients and mottled hyperpigmentation was seen in 20% patients. In our study, commonest histopathological feature of alopecia was perifollicular fibrosis seen in 65% patients, basal cell vacuolization was seen in 52.5% patients,perifollicular lymphocytic infiltrate were seen in 50% patients, epidermal atrophy seen in 35% patients and hyperkeratosis was seen in 20% patients.

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Section: Discussionmentioning

confidence: 99%

A clinical and histopathological study of cicatricial alopecia

Puri¹,

Puri²

2013

Our Dermatol Online

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“…Pseudopelade of Brocq can, at times, be impossible to differentiate from lichen planopilaris, and arguably may represent a variant of lichen planopilaris, as will be discussed. 133 As with DLE, end-stage lichen planopilaris can mimic other primary cicatricial alopecias, including those with a predilection for central scalp involvement. Pathology.…”

Section: Lichen Planopilarismentioning

confidence: 99%

“…Many continue to maintain that pseudopelade of Brocq is distinct clinicopathologically. [173][174][175][176][177][178] Others view it as a variant of certain primary cicatricial alopecias, 66,133,[179][180][181][182] namely, lichen planopilaris and DLE, or alternatively, as the common final stage of several cicatricial alopecias (état pseudopeladique). 183,184 To confuse matters, the term pseudopelade alone is used indiscriminately in the literature to denote both pseudopelade of Brocq and other forms of cicatricial alopecia that simulate it; definition is required each time the term is used.…”

Section: Graham-little Syndromementioning

confidence: 99%

Update on primary cicatricial alopecias

Ross

Tan

Shapiro

2005

Journal of the American Academy of Dermatology

253

323

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“…Although some authors still consider it to be a separate entity, its existence as such is currently doubted by many [26,27,28,29]. Although there are multiple theories about the true nature of PB, the dermatologists that focus on the subject currently tend to consider it not as a nonspecific clinical-pathological entity, but instead, as a variant of some types of PSAs [30,31,32,33,34,35], or, alternatively, as a final atrophic stage of scarring alopecias, such as LE, LPP, or FD [36,37]. At present, the majority of idiopathic noninflammatory scarring alopecia cases are diagnosed as nonspecific scarring alopecia or pseudopelade, and the eponym Brocq is rarely used.…”

Section: Discussionmentioning

confidence: 99%

Primary Scarring Alopecia: Clinical-Pathological Review of 72 Cases and Review of the Literature

Villablanca

Fischer

García-García

et al. 2017

Skin Appendage Disord

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Purpose of the Study: To analyze the epidemiologic, demographic, clinical, and histological characteristics of primary scarring alopecia (PSA) cases diagnosed over a 7-year period at the Department of Dermatology, Hospital Clinic, Barcelona, Spain. Procedures: Seventy-two patients diagnosed with PSA between 2006 and 2012 were included. Age, sex, ethnic group, clinical pattern, predominant histological infiltrate, final clinical diagnosis, time of onset, treatments used, and clinical evolution were evaluated and correlated. Results: The ethnic groups were distributed as follows: 93% European-Caucasian, 5% Mestizo-American, 1% oriental, and 1% Afro-American. Most cases were females (71%), and mean age was 51 ± 6 years. The follicular pattern was the most common, and the predominant inflammatory infiltrate was lymphocytic. Lichen planopilaris and frontal fibrosing alopecia were the main diagnoses. When correlating clinical aspects and histopathology, lymphocytic PSAs had a subacute onset and resulted in a nonchanging, more stable form, while neutrophilic PSAs had a more acute onset with an evolution of acute outbreaks. PSAs in a late stage with an absent/mild infiltrate had a subclinical onset and a slowly progressive or stable evolution. Conclusions: The PSAs are severe trichological conditions. Their high clinical and histopathological variability make them a diagnostic and therapeutic challenge. Message of the Paper: Knowing the clinical and histopathological aspects of PSAs should be of crucial importance to the dermatologist.

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A clinicopathological study of scarring alopecia

Abstract: We have studied 10 cases of scarring alopecia, and investigated the diagnostic reliability of immunofluorescence and histopathology in lichen planopilaris and pseudopelade. In the light of our findings, we discuss the possible pathomechanisms of both disease processes.

Cited by 46 publications

References 12 publications

A clinical and histopathological study of cicatricial alopecia

A clinical and histopathological study of cicatricial alopecia

Update on primary cicatricial alopecias

Primary Scarring Alopecia: Clinical-Pathological Review of 72 Cases and Review of the Literature

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