A clinicopathological study of dysfunctional uterine bleeding

Katuwal, Neeta; Gurung, Geeta; Rana, Ashma; Jha, Abhimanyu Kumar

doi:10.3126/jpn.v4i8.11500

Cited by 6 publications

(6 citation statements)

References 3 publications

(1 reference statement)

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“…However, iatrogenic DUB is due to drugs, exogenous hormone administration, intrauterine contraceptive devices. 5 AUB is a common problem imposing a significant impact on quality of life and financial burden in women of reproductive age group and it occurs in about 9-14% of women. About one third of hysterectomies are carried out for menstrual disorder alone and thyroid dysfunction is one of the important cause.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Abnormal Uterine Bleeding (AUB) with Thyroid Profile and Endometrial Biopsy

Koirala

Pande

Shrestha³

2021

Nep. Med. Coll. J.

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Abnormal uterine bleeding (AUB) is defined as any change in the frequency of menstruation, duration of flow or amount of loss. Menstrual disturbances and different endometrial pattern may accompany and precede thyroid dysfunction. The objective of the study was to correlate thyroid profile with endometrial biopsy in cases of AUB. This study was conducted on 74 patients who presented with AUB, had undergone TFT and endometrial biopsy/hysterectomy. Among 74 patients, thyroid disorders were identified in 26 patients. Maximum number of patients with AUB belonged to the category of hypothyroidism (27%) and 8.1% of cases had hyperthyroidism. In the present study 29 (39.1%) had proliferative endometrium, followed by secretory pattern in 21 (28.4%) patients. Hormone induced changes was seen in 3 (4.1%) patients. Disordered proliferative endometrium and endometrial hyperplasia was observed in 6 patients (8.1%) each. Malignant lesion was not common and it comprised of only 1.4% cases. AUB is frequently seen in patients with thyroid dysfunction. Thyroid function test is a cost effective, easily available test and can detect a possibly curable cause of AUB and avoid unnecessary intervention like hormonal treatment and hysterectomy. AUB due to endometrial cause is an age related pathology. Histopathological examination of endometrial biopsy is a major diagnostic tool in evaluation of AUB. It helps the physician to plan therapy for successful management of AUB.

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Section: Introductionmentioning

confidence: 99%

Correlation of Abnormal Uterine Bleeding (AUB) with Thyroid Profile and Endometrial Biopsy

Koirala

Pande

Shrestha³

2021

Nep. Med. Coll. J.

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“…We found atrophic endometrium in 3.26% of cases whereas Nayak et al, in 2.5% of cases 7 , Katuwal et al, in 68% of cases 24 . Atrophic endometrium was observed in cases of more than 50 years of age.…”

Section: Discussionmentioning

confidence: 46%

Clinico-Pathological Evaluation of Patients With Abnormal Uterine Bleeding

Anwar¹,

Jamal²,

Anwar³

2021

PAFMJ

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Objective: To evaluate clinical spectrum in women of different age groups presenting with menstrual irregularities without any organic pelvic pathology and to correlate clinical and pathological aspects in these women. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Gynecology and Obstetrics, Pakistan Naval Ship (PNS) Shifa Hospital, Karachi from Feb 2018 to Jan 2019. Methodology: Complete history, clinical examination, laboratory investigations, pelvic scan and endometrial biopsy of patients were done to diagnose abnormal uterine bleeding without organic (structural) pathology. Evaluation of clinical spectrum of menstrual irregularities in different age groups and histopathology of their endometrial samples was done. Results: A total of 184 cases were included. Mean age of patients presented with abnormal uterine bleeding was 38.49 ± 9.158. It was most common in the age group 41-50 years (41.84%) followed by 31-40 years (29.34%). Majority of them were multipara 146 (79.34%). The most common presentation was heavy menstrual bleeding (50.54%) followed by irregular menstrual bleeding (17.93%). Histopathology of endometrium revealed proliferative (41.30%) followed by hyperplastic (27.71%) and secretory (21.19%) pattern. 3.26% had atrophic endometrium and 1.63% cases had endometrial carcinoma. Conclusion: In conclusion, 41-50 year age group was mostly affected by abnormal uterine bleeding. Their menstrual pattern was heavy, irregular, frequent and prolonged. Proliferative and hyperplastic pattern of endometrium was observed in these patients.

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“…8 Nepal et al also concluded that the most common age group of women with AUB was 40-44y. 9 In Gubbal et al study, 39.4% of cases belong to 41-50y and 33.5% to 31-40y. 10 In Rizwi et al, Muzaffar et al, and Jairajpur et al study, the majority of cases belonged to the fifth decade.…”

Section: Discussionmentioning

confidence: 88%

Clinical bleeding patterns and management of abnormal uterine bleeding in non-pregnant women: a cross-sectional study

Gupta,

Singh,

Aditya

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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Background: Around 10 to 15 percent of women go through instances of unusual bleeding from their uterus at some point during their reproductive years. Additionally, up to one-third of women may come across irregular menstrual cycles. These irregularities often occur during two crucial phases in a woman's life: firstly, at the beginning of menstruation, which is known as menarche, and secondly, during the transition leading up to menopause, referred to as perimenopause. Aim of study was to determine the clinical bleeding patterns in nonpregnant women and its management. Methods: During the study period spanning from November 2021 to December 2022, a cross-sectional study examined non-pregnant females aged 15 to 55 experiencing abnormal vaginal bleeding (AUB) who provided consent. However, certain exclusion criteria were established to ensure that the study's findings remained pertinent to the target population. Females exhibiting vaginal bleeding attributed to pregnancy or pregnancy-related factors were excluded from the study, as were those with vaginal bleeding stemming from vaginitis, cervical benign, premalignant, or malignant conditions, or traumatic causes. Descriptive statistics were employed in the study. Results: Structural causes [PALM] accounts for 71 (61%) of cases whereas non-structural causes of chronic AUB account for 44 (39%) of cases. AUB-L, 45 (39.2%) was the most frequent finding in females with AUB. The second most common causes are AUB-O 23 (20%) followed by AUB-A 14 (12.2%), AUB-C 08(7%), AUB-M 07 (6.1%), AUB-E 06 (5.2%), AUB-P and AUB-I in 05 (4.3%) each and AUB-N 02 (1.7%). Conclusions: Focusing on Abnormal Uterine Bleeding (AUB), it was observed that AUB-L, attributed to leiomyomas, emerged as the most prevalent cause among affected females. Subsequently, AUB-O, arising from ovulatory dysfunction, and aub-a, linked to adenomyosis, ranked as the second and third most common causes, respectively. Among the clinical manifestations of AUB, prolonged bleeding was identified as the most frequent symptom, followed closely by heavy bleeding.

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A clinicopathological study of dysfunctional uterine bleeding

Cited by 6 publications

References 3 publications

Correlation of Abnormal Uterine Bleeding (AUB) with Thyroid Profile and Endometrial Biopsy

Correlation of Abnormal Uterine Bleeding (AUB) with Thyroid Profile and Endometrial Biopsy

Clinico-Pathological Evaluation of Patients With Abnormal Uterine Bleeding

Clinical bleeding patterns and management of abnormal uterine bleeding in non-pregnant women: a cross-sectional study

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