A clinicopathological and immunohistochemical study of central nervous system hemangiopericytomas

Challa, Sundaram; Uppin, Shantveer G; Uppin, Megha S; Jinkala, Sreerekha; Panigrahi, Manas; Purohit, A K; Rammurti, S.

doi:10.1016/j.jocn.2009.08.018

Cited by 28 publications

(16 citation statements)

References 20 publications

(25 reference statements)

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“…They are still described by many to arise from pericytes, which are modified smooth muscle cells typically found around postcapillary venules [2]. A group at the WHO, however, is proposing that HPCs show no pericytic differentiation and are more fibroblastic in nature, placing them along the continuum of the cellular form of SFTs [3]. The histopathology of our first case was consistent with a WHO grade II and had the typical ''staghorn'' type vessels with focal mild to moderate cellularity.…”

Section: Discussionmentioning

confidence: 99%

“…The updated WHO classification of Tumors of Soft Tissue and Bone, categorized HPCs as fibroblastic with no evidence of pericytic differentiation [2]. This suggests that HPCs are a continuum with solitary fibrous tumors (SFT) due to their similar characteristics, and are often only separated by histopathology [3]. Most HPCs occur outside the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

et al. 2013

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Purpose Hemangiopericytoma (HPC) is a rare tumor of the central nervous system. Primary spinal occurrence of this tumor is extremely uncommon and cases involving the intramedullary spinal cord are even more rare. The purpose of this study was to explore the clinical features, surgical strategies, outcome and pathology in a consecutive series of patients treated at a single institution. Methods The authors performed a retrospective review of the clinicopathological characteristics of four patients with a pathological diagnosis of spinal HPC. Results Four cases with intradural as well as intra/extramedullary components were identified. Gross total resection with no recurrence at the operative site was achieved in the majority of patients with a spinal HPC. One patient had significant recurrence and eventually, succumbed to the disease. Conclusion Increased awareness of these tumors' capability to occur intradurally and intramedullarly can help surgeons accurately diagnose and choose an effective plan of care. Gross total resection of hemangiopericytomas is the mainstay of treatment and should be pursued if feasible. Histopathology is essential to the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

et al. 2013

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“…However, the number of cases was too small for statistical significance. Vuorinen et al reported that the patients with a Ki-67 index less than 5% tended to survive longer, but this finding could not correlate the clinical outcome46,47). Also we conducted statistical analysis of RFS depending on the WHO grade, but we could not find statistical significance ( p =0.644).…”

Section: Discussionmentioning

confidence: 80%

Clinical Analysis of Intracranial Hemangiopericytoma

Park

Kim

Hong

et al. 2013

J Korean Neurosurg Soc

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ObjectiveIntracranial hemangiopericytomas (HPCs) are rare tumors with aggressive behavior, including local recurrence and distant metastasis. We conducted this retrospective study to evaluate the efficacy of grossly total resection and adjuvant radiotherapy (RT) for these tumors.MethodsA total of 13 patients treated for intracranial HPC from January 1995 through May 2013 were included in this retrospective study. We analyzed the clinical presentations, radiologic appearances, treatment results, and follow-up outcomes, as well as reviewed other studies.ResultsThe ages of the patients at the time of diagnosis ranged from 26 to 73 years (mean : 48 years). The majority of the patients were male (92.3%), and the majority of the tumors were located in the parasagittal and falx. The ratio of intracranial HPCs to meningiomas was 13 : 598 in same period, or 2.2%. Seven patients (53.8%) had anaplastic HPCs. Nine patients (69.2%) underwent gross total tumor resection in the first operation without mortality. Eleven patients (84.6%) underwent postoperative adjuvant RT. Follow-up period ranged from 13 to 185 months (mean : 54.3 months). The local recurrence rate was 46.2% (6/13), and there were no distant metastases. The 10-year survival rate after initial surgery was 83.9%. The initial mean Karnofsky performance scale (KPS) was 70.8 and the final mean KPS was 64.6.ConclusionGross total tumor resection upon initial surgery is very important. We believe that adjuvant RT is helpful even with maximal tumor resection. Molecular biologic analyses and chemotherapy studies are required to achieve better outcomes in recurrent intracranial HPCs.

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“…For solitary fibrous tumors, there are no whorls, storiform patterns, mitoses, or psammoma bodies, and they are composed of fascicles of elongated cells in a collagen-rich stroma. 46 …”

Section: Pathological Featuresmentioning

confidence: 99%