A clinicopathologic study on neural invasion in cancer of the pancreatic head

Nagakawa, Takukazu; Kayahara, Masato; Ueno, Koichi; Ohta, Tetsuo; Konishi, Ichiro; Ueda, Nobuhiko; Miyazaki, Itsuo

doi:10.1002/1097-0142(19920215)69:4<930::aid-cncr2820690416>3.0.co;2-r

Cited by 95 publications

(51 citation statements)

References 8 publications

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“…Several detailed pathohistologic studies (Nagakawa et al, 1992a;Nakao et al, 1996) have shown that PNI is one of the causes of locoregional recurrence in resected pancreatic cancer. But the prognostic value of PNI is not clear.…”

Section: Discussionmentioning

confidence: 99%

Influence of Perineural Invasion on Survival and Recurrence in Patients with Resected Pancreatic Cancer

Zhang¹,

Hua²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Influence of Perineural Invasion on Survival and Recurrence in Patients with Resected Pancreatic Cancer

Zhang¹,

Hua²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In the pancreatic carcinoma, nerve invasion is the major pathway in the retroperitoneal direction [24]. In rectal carcinoma, neural invasion has a strong relationship with local recurrence of the tumor [25].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of gastric carcinoma in high- and low-mortality countries: Comparison between Japan and the United States

et al. 1998

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Abstract:Background. Gastric carcinoma is a tumor that shows marked differences in geographic distribution. The incidence of the gastric carcinoma has been falling dramatically in Western countries. In sharp contrast, the incidence in Japan is still quite high. Methods. A comparative clinicopathological study was performed, examining gastric carcinomas in 978 Japanese patients (Tokyo) and 157 United States patients (San Diego), that had been surgically resected over the 11-year period 1980-1991. Results. The median age of US the patients (64.1 years) was higher than that of the Japanese patients (59.0 years). There was no difference in the sex ratios. Forty-five of the Japanese patients had early gastric cancer, while this occurred in 10% of the US patients. In terms of tumor location, 47% were in the upper portion of the stomach in the US patients, while, in contrast, this proportion in Japanese patients was 23%. In association with the marked difference in tumor location, 36.5% of the US patients underwent operations with the thoraco-abdominal approach, while this approach was used in 7.5% of the Japanese patients. The distribution of histological types was similar in the two countries' samples. There was also no significant difference in the distribution of the histological types in the same age groups in the two countries' samples. The rate of the well differentiated type increased with age while the rate of poorly differentiated type decreased. In US patients, 35.8% had marked neural invasion, while this occurred in 8.5% of Japanese patients. Conclusion. This study revealed marked differences in the features of gastric cancer between the US and Japan in terms of tumor location and surgical procedures.Key words: gastric carcinoma, gastric cancer, epidemiology, histological type of gastric carcinoma, international comparison Offprint requests to: M. Maruyama

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“…The clinical significance of carcinoma invasion into the extratumoral nerve plexus was studied in pancreatic cancer [18,19]. Nakao et al [19] reported that intrapancreatic neural invasion was observed in 116 of 120 (90%), of which 80 (69%) showed extrapancreatic nerve involvement.…”

Section: Discussionmentioning

confidence: 99%

Rationale of pelvic autonomic nerve preservation in rectal cancer surgery based on immunohistochemical study

et al. 2010

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A clinicopathologic study on neural invasion in cancer of the pancreatic head

Cited by 95 publications

References 8 publications

Influence of Perineural Invasion on Survival and Recurrence in Patients with Resected Pancreatic Cancer

Influence of Perineural Invasion on Survival and Recurrence in Patients with Resected Pancreatic Cancer

Clinicopathological study of gastric carcinoma in high- and low-mortality countries: Comparison between Japan and the United States

Rationale of pelvic autonomic nerve preservation in rectal cancer surgery based on immunohistochemical study

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