A clinicopathologic study of atypical lesions of the breast

Ashikari, Roy; Huvos, Andrew G.; Snyder, Ruth E.; Lucas, John C.; Hutter, R. V. P.; McDivitt, Robert W.; Schottenfeld, David

doi:10.1002/1097-0142(197402)33:2<310::aid-cncr2820330203>3.0.co;2-c

Cited by 59 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concept of atypical hyperplasia was introduced decades ago within the continuum of intraductal breast proliferations, a continuum which encompasses benign proliferations of usual ductal hyperplasia to high-grade ductal carcinoma in situ (DCIS) [3–5, 7, 15, 32]. The term atypical ductal hyperplasia (ADH) was used initially for a vaguely defined group lesions that had “some but not all of the requisite features of ductal carcinoma in situ” [21].…”

Section: Introductionmentioning

confidence: 99%

Discrepancies in the diagnosis of intraductal proliferative lesions of the breast and its management implications: results of a multinational survey

2006

View full text Add to dashboard Cite

To measure discrepancies in diagnoses and recommendations impacting management of proliferative lesions of the breast, a questionnaire of five problem scenarios was distributed among over 300 practicing pathologists. Of the 230 respondents, 56.5% considered a partial cribriform proliferation within a duct adjacent to unequivocal ductal carcinoma in situ (DCIS) as atypical ductal hyperplasia (ADH), 37.7% of whom recommended reexcision if it were at a resection margin. Of the 43.5% who diagnosed the partially involved duct as DCIS, 28.0% would not recommend reexcision if the lesion were at a margin. When only five ducts had a partial cribriform proliferation, 35.7% considered it as DCIS, while if ≥20 ducts were so involved, this figure rose to 60.4%. When one duct with a complete cribriform pattern measured 0.5, 1.5, or 4 mm, a diagnosis of DCIS was made by 22.6, 31.3, and 94.8%, respectively. When multiple ducts with flat epithelial atypia were at a margin, 20.9% recommended reexcision. Much of these discrepancies arise from the artificial separation of ADH and low-grade DCIS and emphasize the need for combining these two under the umbrella designation of ductal intraepithelial neoplasia grade 1 (DIN 1) to diminish the impact of different terminologies applied to biologically similar lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

Discrepancies in the diagnosis of intraductal proliferative lesions of the breast and its management implications: results of a multinational survey

2006

View full text Add to dashboard Cite

show abstract

“…For example papillary lesions are better classified after multiple paraffin sections are carefully studied [16]. Furthermore, limitations in calcified lesions are recognized due to geometry and histological heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions

et al. 2009

View full text Add to dashboard Cite

BackgroundLimited data are available to evaluate the accuracy of frozen section analysis and ultrasound- guided core needle biopsy of the breast.MethodsIn a retrospective analysis data of 120 consecutive handheldultrasound- guided 14- gauge automated core needle biopsies (CNB) in 109 consecutive patients with breast lesions between 2006 and 2007 were evaluated.ResultsIn our outpatient clinic120 CNB were performed. In 59/120 (49.2%) cases we compared histological diagnosis on frozen sections with those on paraffin sections of CNB and finally with the result of open biopsy. Of the cases 42/59 (71.2%) were proved to be malignant and 17/59 (28.8%) to be benign in the definitive histology. 2/59 (3.3%) biopsies had a false negative frozen section result. No false positive results of the intraoperative frozen section analysis were obtained, resulting in a sensitivity, specificity and positive predicting value (PPV) and negative predicting value (NPV) of 95%, 100%, 100% and 90%, respectively. Histological and morphobiological parameters did not show up relevance for correct frozen section analysis. In cases of malignancy time between diagnosis and definitive treatment could not be reduced due to frozen section analysis.ConclusionThe frozen section analysis of suspect breast lesions performed by CNB displays good sensitivity/specificity characteristics. Immediate investigations of CNB is an accurate diagnostic tool and an important step in reducing psychological strain by minimizing the period of uncertainty in patients with breast tumor.

show abstract

“…was not universally acceptable (Gallagher and Martin 1969 ;Black et al 1972 ;Ashikari et al 1974 ). felt strongly that the term atypical hyperplasia was inappropriate and believed this would 'frighten surgeons into performing unnecessary mastectomies'.…”

Section: Atypical Ductal Hyperplasia (Adh)mentioning

confidence: 99%

Benign Breast Diseases

Chinyama¹

2014

View full text Add to dashboard Cite

A clinicopathologic study of atypical lesions of the breast

Cited by 59 publications

References 9 publications

Discrepancies in the diagnosis of intraductal proliferative lesions of the breast and its management implications: results of a multinational survey

Discrepancies in the diagnosis of intraductal proliferative lesions of the breast and its management implications: results of a multinational survey

The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions

Benign Breast Diseases

Contact Info

Product

Resources

About