A Clinicopathologic Report of the Retinal Lesions Associated With Didanosine

Multimodal Imaging in Didanosine Retinopathy

“…The patient was asymptomatic and the retinopathy was detected during a routine examination. This case report adds to previously reported cases of didanosine retinopathy [1][2][3]5,6,8,9 and describes the findings from different imaging modalities in retinopathy caused by didanosine.…”

“…One interesting feature of didanosine retinopathy is the total sparing of the macula. This was also demonstrated using light microscopy in the study by Whitcup et al 8 who reported that the neurosensory retina, the RPE, and the choroid were normal in the macula. The sparing of the macula could be due to the unique cellular and molecular features of the macula as opposed to the peripheral retina.…”

Multimodal Imaging in Didanosine Retinopathy

“…The patient was asymptomatic and the retinopathy was detected during a routine examination. This case report adds to previously reported cases of didanosine retinopathy [1][2][3]5,6,8,9 and describes the findings from different imaging modalities in retinopathy caused by didanosine.…”

“…One interesting feature of didanosine retinopathy is the total sparing of the macula. This was also demonstrated using light microscopy in the study by Whitcup et al 8 who reported that the neurosensory retina, the RPE, and the choroid were normal in the macula. The sparing of the macula could be due to the unique cellular and molecular features of the macula as opposed to the peripheral retina.…”

Didanosine-Associated Retinal Toxicity (DART) Amongst HIV-Positive Patients: a Case Series and Literature Review

“…Often there is relative sparing of a far peripheral retinal crescent (see Figs. 1 and 5) and Whitcup's histological description of DART in a child also details an unaffected 3 mm region posterior to the ora serrata [18]. The optic disc and vasculature appeared normal in all our cases, and only 2 out of 19 previous cases reported any arterial narrowing [8,9], and one reported optic disc waxy pallor [8].…”

A woman with didanosine retinopathy and non-cirrhotic portal hypertension

“…Electronic microscopy showed numerous lamellar inclusions and cytoplasmic bodies in the RPE cells. 3 One year later a similar clinical picture was described in an adult, 4 who had unaffected visual acuity and normal electrophysiology. Four other cases in adults have been described since.…”

Multimodal Imaging in Didanosine Retinopathy

“…The patient was asymptomatic and the retinopathy was detected during a routine examination. This case report adds to previously reported cases of didanosine retinopathy [1][2][3]5,6,8,9 and describes the findings from different imaging modalities in retinopathy caused by didanosine.…”

“…One interesting feature of didanosine retinopathy is the total sparing of the macula. This was also demonstrated using light microscopy in the study by Whitcup et al 8 who reported that the neurosensory retina, the RPE, and the choroid were normal in the macula. The sparing of the macula could be due to the unique cellular and molecular features of the macula as opposed to the peripheral retina.…”

Didanosine-Associated Retinal Toxicity (DART) Amongst HIV-Positive Patients: a Case Series and Literature Review

“…Often there is relative sparing of a far peripheral retinal crescent (see Figs. 1 and 5) and Whitcup's histological description of DART in a child also details an unaffected 3 mm region posterior to the ora serrata [18]. The optic disc and vasculature appeared normal in all our cases, and only 2 out of 19 previous cases reported any arterial narrowing [8,9], and one reported optic disc waxy pallor [8].…”

A woman with didanosine retinopathy and non-cirrhotic portal hypertension

“…Electronic microscopy showed numerous lamellar inclusions and cytoplasmic bodies in the RPE cells. 3 One year later a similar clinical picture was described in an adult, 4 who had unaffected visual acuity and normal electrophysiology. Four other cases in adults have been described since.…”

Multimodal Imaging in Didanosine Retinopathy

“…The patient was asymptomatic and the retinopathy was detected during a routine examination. This case report adds to previously reported cases of didanosine retinopathy [1][2][3]5,6,8,9 and describes the findings from different imaging modalities in retinopathy caused by didanosine.…”

“…One interesting feature of didanosine retinopathy is the total sparing of the macula. This was also demonstrated using light microscopy in the study by Whitcup et al 8 who reported that the neurosensory retina, the RPE, and the choroid were normal in the macula. The sparing of the macula could be due to the unique cellular and molecular features of the macula as opposed to the peripheral retina.…”

Didanosine-Associated Retinal Toxicity (DART) Amongst HIV-Positive Patients: a Case Series and Literature Review

“…Often there is relative sparing of a far peripheral retinal crescent (see Figs. 1 and 5) and Whitcup's histological description of DART in a child also details an unaffected 3 mm region posterior to the ora serrata [18]. The optic disc and vasculature appeared normal in all our cases, and only 2 out of 19 previous cases reported any arterial narrowing [8,9], and one reported optic disc waxy pallor [8].…”

A woman with didanosine retinopathy and non-cirrhotic portal hypertension

“…Electronic microscopy showed numerous lamellar inclusions and cytoplasmic bodies in the RPE cells. 3 One year later a similar clinical picture was described in an adult, 4 who had unaffected visual acuity and normal electrophysiology. Four other cases in adults have been described since.…”