A clinicopathologic and immunohistochemical study of ten pancreatic lymphangiomas and a review of the literature

Paal, Edina; Thompson, Lester D.�R.; Heffess, Clara S.

doi:10.1002/(sici)1097-0142(19980601)82:11<2150::aid-cncr9>3.0.co;2-z

Cited by 127 publications

(105 citation statements)

References 37 publications

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“…The final diagnosis is histological [1] , with the endothelial cells showing immunohistochemical reactivity to factor VIII/R antigen, CD 31 (+) positivity [6,8] and CD 34 (-) negativity [6] , as seen in our patient.…”

supporting

confidence: 56%

“…It occurs more frequently in females and is often located in the distal pancreas [5] . The tumour size may vary between 3 and 20 cm in diameter (average 12 cm) [6] . Patients usually present with abdominal pain [5] and an associated palpable abdominal mass [7][8][9] , although an acute abdomen has also been described [10] .…”

Section: Discussionmentioning

confidence: 99%

“…A complete surgical excision is curative [6,8,15] , with incomplete excision being the only reason for recurrent disease [7] . Depending on the tumour location and size, complete excision may involve a simple marginal tumorectomy [10] or may require larger pancreatic resections with anastomoses.…”

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confidence: 99%

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Cystic lymphangioma of the pancreas

Colović¹,

Grubor²,

Micev³

et al. 2008

WJG

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supporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

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Cystic lymphangioma of the pancreas

Colović¹,

Grubor²,

Micev³

et al. 2008

WJG

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“…Lymphangiomas may also present as pancreatic and peripancreatic cystic masses, 181,182 and may closely mimic LECs (especially those with denuded epithelium) because they also contain prominent lymphoid tissue. Lymphangiomas are lined by endothelial cells as demonstrated by immunohistochemical labeling for endothelial markers (CD31, CD34 or D2-40) and lack staining for epithelial markers (cytokeratins).…”

Section: Lymphangiomasmentioning

confidence: 99%

Cystic lesions of the pancreas

Adsay

2007

Modern Pathology

188

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Although cystic tumors of the pancreas are relatively rare, they constitute an increasingly important category. Advances in imaging and interventional techniques and the sharp drop in the mortality rate of pancreatic surgery have rendered pancreatic biopsies and resections commonplace specimens. Consequently, in the past two decades, the nature of many cystic tumors in this organ has been better characterized. The names of some existing entities were revised; for example, what was known as papillary-cystic tumor is now regarded as solidpseudopapillary tumor. New entities, in particular, intraductal papillary mucinous neoplasm and its variants, such as oncocytic and intestinal subtypes were recognized. The importance of clinical and pathologic correlation in the evaluation of these lesions was appreciated, in particular, with regards to the multifocality of these lesions, their association with invasive carcinomas, and thus their 'preinvasive' nature. Consensus criteria for the distinction of these from the ordinary precursors of adenocarcinoma, the pancreatic intraepithelial neoplasia, were established. The definition of mucinous cystic neoplasms was refined; ovarian-like stroma has now become almost a requirement for the diagnosis of mucinous cystic neoplasia, and defined as such, the propensity of these tumors to occur in perimenopausal women became even more striking. The validity and clinical value of classifying the pancreatic cysts of mucinous type as adenoma, borderline, CIS and invasive have been established. Related to this, the importance of thorough sampling in accurate classification of these mucinous lesions was recognized. Greater accessibility of the pancreas afforded by improved invasive as well as noninvasive modalities has also increased the detection of otherwise clinically silent cystic tumors, which has led to the recognition of more innocuous entities such as acinar cell cystadenoma and squamoid cyst of pancreatic ducts. As the significance of the cystic lesions emerged, cystic forms of otherwise typically solid tumors were also better characterized. Thus, significant developments have taken place in the classification and our understanding of pancreatic cystic tumors in the past few years, and experience with these lesions is likely to grow exponentially in the coming years. Modern Pathology (2007) 20, S71-S93.

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“…Pancreatic cystic lymphangiomas (PCL) are extremely rare lesions with only a few cases reported in literature (2). Pancreatic cystic lymphangiomas are most often solitary lesions…”

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confidence: 99%