A clinicopathologic and immunohistochemical study of primary and secondary breast angiosarcoma

Abada, Evi; Jang, Hyejeong; Kim, Seongho; Ali-Fehmi, Rouba; Bandyopadhyay, Sudeshna

doi:10.4132/jptm.2022.08.31

Cited by 3 publications

(5 citation statements)

References 33 publications

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“…Breast angiosarcomas are classified as primary breast angiosarcoma (PBA) and secondary breast angiosarcoma (SBA). However, in terms of histology, IHC (CD117, c-Myc, P53) and survival, there is no difference between PBA and SBA ( 1 ). Primary angiosarcomas are rarer, with the breast being the most common site.…”

Section: Discussionmentioning

confidence: 91%

A case report of primary angiosarcoma of the breast

Huang¹,

Xian²,

Zhou³

et al. 2023

Transl Cancer Res

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Background: Breast Angiosarcoma can be divided into primary breast angiosarcoma (PBA) and second breast angiosarcoma (SBA). PBA is rare malignant breast cancer with poor outcomes. PBA usually occurs in women between 30-40 years old. PBA does not have a specific clinical manifestation. Clinically, PBA presents with a rapidly enlarging breast mass and skin involvement with skin color changes. Ultrasonography of PBA can be hypoechoic or hyperechoic, or mixed disordered areas. Microscopically, PBA can be classified into three grades according to the degree of differentiation, and the grade is related to the prognosis. And PBA can also express vascular endothelial markers. The main treatment for PBA is surgery, especially mastectomy. There are other treatments, such as chemotherapy and radiotherapy, but their effectiveness needs further confirmation. Targeted drugs may be helpful.Case Description: A 32-year-old woman with main clinical presentation of a rapidly growing mass located in the upper inner quadrant of the right breast with skin involvement. PBA was diagnosed with first extended local resection, and then the patient underwent a second right mastectomy. The patient is now undergoing chemotherapy.Conclusions: Since this is a rare form of breast cancer, we report this case to raise the attention of breast surgeons to avoid misdiagnoses.

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Section: Discussionmentioning

confidence: 91%

A case report of primary angiosarcoma of the breast

Huang¹,

Xian²,

Zhou³

et al. 2023

Transl Cancer Res

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“…The highly malignant and aggressive form may present a more chaotic architecture organized as multilayered abnormal endothelial cells with poorly defined vascular spaces, atypical nuclei, and papillary-like projections. [7,[30][31][32] The poorly differentiated forms present diagnostic challenges due to heterogeneous cytological features and nonspecific characteristics similar to melanoma or anaplastic carcinoma. Thus, immunohistochemical analysis is necessary in the differential diagnosis of poorly differentiated AS types.…”

Section: Etiology Diagnostic Imaging Histopathology and Pathogenesis ...mentioning

confidence: 99%

“…In cases of progressive tumor dedifferentiation, AS is distinguished from melanoma by negativity for melanocytic markers. [7,31,32] Pathogenic progression of AS remains enigmatic, and the mechanism is poorly understood due to poor prognosis. Earlier animal studies have well-established the tumorigenic potentials of foreign bodies.…”

Section: Etiology Diagnostic Imaging Histopathology and Pathogenesis ...mentioning

confidence: 99%

Section: Etiology Diagnostic Imaging Histopathology and Pathogenesis ...mentioning

confidence: 99%

“…In cases of progressive tumor dedifferentiation, AS is distinguished from melanoma by negativity for melanocytic markers. [7,31,32]…”

Section: Etiology Diagnostic Imaging Histopathology and Pathogenesis ...mentioning

confidence: 99%

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Etiology, pathogenesis, and management of angiosarcoma associated with implants and foreign body: Clinical cases and research updates

Samargandi

2024

Medicine

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Angiosarcomas are rare and highly malignant soft tissue sarcomas originating from endothelial cells lining the lymphatic or vascular system. While they predominantly emerge from (sub)cutaneous regions, occurrences have been reported throughout the body. The etiology of angiosarcoma remains elusive in most clinical cases. Nevertheless, several prognosis risk factors play a pivotal role, including chronic lymphedema, therapeutic irradiation, environmental carcinogens, familial syndromes, and the presence of foreign materials like metallic objects and biomedical implants. Despite evidence implicating retained foreign material in angiosarcoma development, understanding its prognosis and pathogenesis remains limited. The pathogenesis of angiosarcoma appears to involve a complex interplay of chronic inflammation, tissue remodeling, and genetic factors that create a conducive microenvironment for malignant transformation. Management of these sarcomas remains challenging due to their infiltrative nature owing to the high chance of metastasis and local recurrence. The primary treatment modalities currently include surgery, radiotherapy, and chemotherapy, but recent advances in targeted immunotherapy and gene therapy hold promise for more effective approaches. This comprehensive review delves into the potential etiological and pathogenic roles of foreign materials, such as metallic objects, biomedical implants, and biomaterials, in the development of angiosarcoma. Further research into the underlying molecular mechanisms could provide valuable insights for tailored management and developing novel targeted therapeutic strategies.

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Primary ovarian angiosarcoma: Two case reports and review of literature

Zhou¹,

Sun²,

Liu³

et al. 2023

World J Clin Cases

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The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.

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A clinicopathologic and immunohistochemical study of primary and secondary breast angiosarcoma

Cited by 3 publications

References 33 publications

A case report of primary angiosarcoma of the breast

A case report of primary angiosarcoma of the breast

Etiology, pathogenesis, and management of angiosarcoma associated with implants and foreign body: Clinical cases and research updates

Primary ovarian angiosarcoma: Two case reports and review of literature

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