A clinicoetiological analysis of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis treated at Sohag University Hospital, Egypt

El‐Hamd, Mohammed Abu; El-Dawla, Reham Ezz; Elmagid, Wafaa Abd

doi:10.1097/01.ewx.0000491262.03254.04

Cited by 4 publications

(6 citation statements)

References 32 publications

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“…In this study, the range of the incubation period from the causative drug intake to the onset of skin reaction was 2 to 23 days with mean of 8.37 ± 3.72 days. This result was in agreement with another study that reported that the range of the incubation period from the drug intake to the onset of skin reaction ranged from 2 to 20 days, with mean of 8.84 ± 5.72 days 17 . Another two studies reported a slightly longer incubation period with means were 14 and 15 days, respectively 32,33 …”

Section: Discussionsupporting

confidence: 92%

“…This result was in agreement with another study that reported that the range of the incubation period from the drug intake to the onset of skin reaction ranged from 2 to 20 days, with mean of 8.84 ± 5.72 days. 17 Another two studies reported a slightly longer incubation period with means were 14 and 15 days, respectively. 32,33 In the current study, the duration of hospitalization ranged from patients with SJS.…”

Section: Resultsmentioning

confidence: 95%

“…This result is in disagreement with a Korean study conducted by Kim et al 34 who showed that the mean hospitalization was 19.7 days. Another Egyptian study conducted by El‐Hamd et al 17 concluded that the mean of hospitalization was 19.6 days. Patients with TEN have a more severe condition and are likely to have longer period of hospitalization than patients with SJS.…”

Section: Discussionmentioning

confidence: 98%

“…Some SCARs can result in serious morbidity and even death 16 . Although SCARs are common, comprehensive information about their incidence, severity and ultimate effects is often not available 17 . In this study, the severe cases of SCARs admitted to the dermatology department were included, while the simple cases of SCARs were treated as outpatients and excluded from the study.…”

Section: Discussionmentioning

confidence: 99%

“…The causative drugs in different types of SCARs is often not available 17. In this study, the severe cases of SCARs admitted to the dermatology department were included, while the simple cases of SCARs were treated as outpatients and excluded from the study.…”

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confidence: 99%

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Severe cutaneous adverse drug reactions: Incidence, clinical patterns, causative drugs and modalities of treatment in Assiut University Hospital, Upper Egypt

Abou-Taleb

El‐Sayed

Ghabesha

et al. 2020

Dermatologic Therapy

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Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and overlap SJS/TEN are life-threatening diseases that are most frequently caused by drugs. Much debate remains about the role of systemic corticosteroids (SCs) in their treatment. Our aim to determine the incidence, causative drugs, the role and side effects of SCs in severe cutaneous adverse reactions (SCARs), in Assiut University Hospital (AUH). Patients This study was conducted in Department of Dermatology at AUH, from 2012 to 2017. All patients with SJS, overlap SJS/TEN and TEN admitted during this period were included in the study. Eighty-three patients with SCARs were included in this study. The most common type was SJS (67.5%). The incidence ranged from 1.7% in 2012 to 7.7% in 2017. Carbamazepine, valproic acid, lamotrigine, diclofenac sodium, and flucloxacillin-amoxicillin were the most common causative drugs. The most common side effects of SCs were peptic ulcer (55.5%) and hypertension (51.8%). The mortality rate in patients treated with SCs was 100% in TEN, 33.3% in overlap SJS/TEN and 16.3% in SJS. The patients of SCARs must be aware of the causative drugs and must never be re-administered. SCs in treatment of SCARs may increase the complications and the mortality rate.

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Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Severe cutaneous adverse drug reactions: Incidence, clinical patterns, causative drugs and modalities of treatment in Assiut University Hospital, Upper Egypt

Abou-Taleb

El‐Sayed

Ghabesha

et al. 2020

Dermatologic Therapy

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Carbamazepine/lamotrigine

2017

Reactions Weekly

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The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China

Yang

Zhang

et al. 2018

Journal of Immunology Research

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Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN. The most common offending drugs were antibiotics (29.5%) and anticonvulsants (24.1%). Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%). Chinese patent medicines accounted for 5.4%. There were 76 (45.8%) patients receiving systemic steroid and intravenous immunoglobulin (IVIG) in combination therapy, especially for TEN (80.3%), and others were treated with systemic steroids alone. Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance. In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation.

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A clinicoetiological analysis of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis treated at Sohag University Hospital, Egypt

Cited by 4 publications

References 32 publications

Severe cutaneous adverse drug reactions: Incidence, clinical patterns, causative drugs and modalities of treatment in Assiut University Hospital, Upper Egypt

Severe cutaneous adverse drug reactions: Incidence, clinical patterns, causative drugs and modalities of treatment in Assiut University Hospital, Upper Egypt

Carbamazepine/lamotrigine

The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China

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