A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors

Krywanczyk, Alison; Tan, Carmela D.; Rodríguez, E. René

doi:10.1007/s11886-021-01548-6

Cited by 5 publications

(4 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supplementary Table S2 presents a summary of the clinical and imaging features reported in primary pericardial sarcomas from published case reports ( 9 – 21 ). Our analysis reveals that these tumors tend to be large, with irregular or ill-defined borders, particularly when their size exceeds 5 cm ( 14 , 15 , 17 , 18 ). Furthermore, central areas of necrosis or hemorrhage may be evident, and there is often a significant degree of pericardial effusion or hemopericardium.…”

Section: Discussionmentioning

confidence: 85%

Multimodality imaging assessment of primary pericardial rhabdomyosarcoma: a case report

Li,

Cao,

Shao

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Primary pericardial sarcomas are rare and lethal diseases. To date, only a few cases of primary pericardial sarcomas, such as rhabdomyosarcoma (RMS), have been reported. Since the unusual location of RMS in the pericardium makes it challenging to diagnose, precise diagnostic procedures are required. In this study, we present the case of a 23-year-old man who experienced postprandial obstruction and atypical precordial pain that lasted for a week. Echocardiography revealed a heterogeneous isoechoic pericardial mass with a significant pericardial effusion. Contrast-enhanced CT revealed a massive pericardial effusion along with an irregular, defined, heterogeneously enhancing mass that was located between the pericardium and diaphragm. PET-CT imaging showed an intense FDG uptake in the pericardial mass. Furthermore, cardiac MRI demonstrated malignant characteristics of the pericardial mass and provided a detailed visualization of its exact anatomical connection with both cardiac and extracardiac structures. Finally, a pathologic examination of a puncture biopsy specimen confirmed the diagnosis of primary pericardial RMS. Our case emphasizes the importance of multimodal imaging for the differential diagnosis and evaluation of cardiac involvement, while providing clinicians with crucial information for clinical treatment and decision-making.

show abstract

Section: Discussionmentioning

confidence: 85%

Multimodality imaging assessment of primary pericardial rhabdomyosarcoma: a case report

Li,

Cao,

Shao

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Previous reports of sites of mediastinal metastasis of a malignant tumor have noted the mediastinal lymph nodes [1], thymus [3], and pericardium [4,5]. Thymic metastasis can be determined based on surgical or pathological findings.…”

Section: Discussionmentioning

confidence: 99%

“…Thymic metastasis can be determined based on surgical or pathological findings. Metastasis to the mediastinal lymph nodes is diagnosed based on pathological findings showing the presence of a primary tumor [6], while that to the pericardium is diagnosed based on surgical findings, cytology findings of pericardial effusion, and/or pathological findings of a biopsy specimen taken from the pericardium [4,5]. Additionally, metastatic tumors to the mediastinum related to various types of carcinomas have been reported to appear as an abnormal enlarged mass in chest CT images, with increased uptake noted in PET findings [7,8].…”

Section: Discussionmentioning

confidence: 99%

Surgical resection of mediastinal metastasis from small cell carcinoma of bladder: case report

Isono

Kimura

et al. 2022

Gen Thorac Cardiovasc Surg Cases

View full text Add to dashboard Cite

Background Isolated mediastinal metastasis from a malignant tumor and small cell carcinoma of the bladder are both very rare. Case presentation A 76-year-old woman who had undergone surgery for bladder cancer twice was referred to our hospital for a right paracardiac mass noted in chest computed tomography findings, and resection of the tumor was performed. Histological analysis of the mediastinal tumor revealed it to be a metastatic small cell carcinoma of the bladder. At 4 months after surgery, multiple metastatic lesions were found in the chest and liver, and chemotherapy for small cell carcinoma was started. Conclusions We present this case of mediastinal metastasis of small cell carcinoma of the bladder, which is very rare, to show the importance of surgical resection of an isolated mediastinal tumor. Such a procedure should be considered, as histological diagnosis of the tumor could be useful for determining therapeutic options.

show abstract

“…PM should be differentiated from other primary neoplasms of the pericardium such as intrapericardial paragangliomas, angiosarcoma, pericardial thymoma, lymphoma, pericardial synovial sarcoma, and schwannomas. 47 These tumors may mimic mesotheliomas morphologically and the distinction can be facilitated using immunohistochemistry, with or without other ancillary studies accordingly. Similarly, immunohistochemistry is essential to distinguish between mesothelioma and metastases.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Pericardial Mesotheliomas

Arrossi¹

2023

Advances in Anatomic Pathology

View full text Add to dashboard Cite

Primary pericardial mesothelioma (PM) is a rare tumor arising from the mesothelial cells of the pericardium. It has an incidence of <0.05% and comprises <2% of all mesotheliomas; however, it is the most common primary malignancy of the pericardium. PM should be distinguished from secondary involvement by the spread of pleural mesothelioma or metastases, which are more common. Although data are controversial, the association between asbestos exposure and PM is less documented than that with other mesotheliomas. Late clinical presentation is common. Symptoms may be nonspecific but are usually related to pericardial constriction or cardiac tamponade, and diagnosis can be challenging usually requiring multiple imaging modalities. Echocardiography, computed tomography, and cardiac magnetic resonance demonstrate heterogeneously enhancing thickened pericardium, usually encasing the heart, with findings of constrictive physiology. Tissue sampling is essential for diagnosis. Histologically, similar to mesotheliomas elsewhere in the body, PM is classified as epithelioid, sarcomatoid, or biphasic, with the biphasic type being the most common. Combined with morphologic assessment, the use of immunohistochemistry and other ancillary studies is helpful for distinguishing mesotheliomas from benign proliferative processes and other neoplastic processes. The prognosis of PM is poor with about 22% 1-year survival. Unfortunately, the rarity of PM poses limitations for comprehensive and prospective studies to gain further insight into the pathobiology, diagnosis, and treatment of PM.

show abstract

A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors

Cited by 5 publications

References 69 publications

Multimodality imaging assessment of primary pericardial rhabdomyosarcoma: a case report

Multimodality imaging assessment of primary pericardial rhabdomyosarcoma: a case report

Surgical resection of mediastinal metastasis from small cell carcinoma of bladder: case report

Pericardial Mesotheliomas

Contact Info

Product

Resources

About