A clinico-histopathological study on skin appendageal tumors

Abstract

Background: Skin Appendageal tumors are a large and diverse group of tumors that are commonly classiied according to their state of appendageal differentiation: follicular, sebaceous, eccrine and apocrine. Objectives of this study were to study the clinic-epidemiological proile of skin appendageal tumors and to correlate the clinico-histopathological diagnosis. Materials and Methods:This was a retrospective and prospective study which included all cases of skin adnexal tumours diagnosed histologically during the period of four and half years. Tumors were analyzed considering the anatomic location, duration, size and type of the tumour, along with age and sex of the patient. The Histological characterization was done according to the WHO classiication system and was correlated with the clinical diagnosis. Collected data were analysed using SPSS PC+ 11.5 Version for statistical analysis.Results: A total of 70 neoplasms of skin appendages included, 68 (97.1%) were benign and 2 (2.9%) was malignant. Female comprised of 47 (67.1%) and 23 (32.9%) were male. The mean age was 39.23 years. Of all, 43 (61.4%) tumors were follicular, 18 (25.7%) were eccrine, 7 (10%) were apocrine and 2 (2.9%) were with sebaceous differentiation. The three commonest tumors encountered in this study were Pilomatricoma (21.4%), Keratoacanthoma (17.1%) and Trichoepithelioma (14.3%). Clinically, 13/70 (18.5%) cases were diagnosed as SAT.

Histopathological study of skin tumours

“…On histopathologically, we found island of hyperchromatic nuclei and scantycytoplasm with peripheral palisading arrangement, aretractionartifact separate the basaloid cells from the surrounding mucinous stroma. In the present study Benign Adnexal Tumours constitutes the majority (80%) which is similar to other India studies [5,10,[14][15][16][17][18]. In the present study the benign sweat gland tumours constitute the most common (87.5%) among all benign skin appendeageal tumours which is similar to other studies done by Ankit Sharma et al (42.86%) and Radhika K et al (48.15%) respectively [14,15].…”

“…Two cases of this tumour were reported in this study. Inthe study conducted by Paudyal P et al (2016) [17], showed 43 cases of Hair follicle tumours were benign. On histopathology tumour showed peripheral palisading of basaloid cells and large keratinocytes with eosinophilic cytoplasm and copious keratinization.…”

Spectrum of Malignant Skin Lesion in Patients attending Nepalgunj Medical College and Teaching Hospital

“…Similar finding was noted by Paudyal Pet al, in which benign appendageal tumor were more common than malignant 14 appendageal tumor.…”

Five‐year pattern of adnexal tumors of the skin in Ethiopia

“…Most other studies also reported female predominance. 11,12,16,19,[22][23][24][25] A larger number of men was reported by a study in Slovakia which found M : F = 1.2 : 1, 1 an Egyptian study which reported M : F = 1.5 : 1, 16 a Moroccan study which found M : F = These differences must be related to the different proportions of the specific tumor types which have gender disparities. For example, syringoma is reported more commonly in females.…”

“…decades. 16 Another study in Iran reported the mean age as 34.5, 17 a study in Nepal reported 39.23, 19 a Nigerian study by Adegoke and Ajani 20 reported 36.6, and a study in Morocco reported 34. 21 These were all in line with our study's findings.…”