A Clinico-Hematological Study of Cases of Leucoerythroblastic Reaction

Waghmare, Tejaswini; Prabhat, Daksha; D, Naveen Vairamoorthy

doi:10.21276/apalm.2410

Cited by 2 publications

(1 citation statement)

References 6 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 In this study, maximum number of cases was seen in 21-30 years age group with male to female ratio of 1.1:1. Shubha HV et al 13 and Waghmare T et al 14 also observed maximum cases in 3 r d decade in their study with no significant sex distribution. On Bone marrow examination, non-neoplastic conditions were seen in 65% cases while neoplastic lesions were seen in 35% cases (Table 2).…”

Section: Discussionmentioning

confidence: 55%

Role of bone marrow aspiration and biopsy in evaluation of leucoerythroblastic blood picture

Sharma

Hans²,

Naz³

2022

PJMS

View full text Add to dashboard Cite

Leucoerythroblastosis was considered as a circulating expression of haematological and non-haematological malignancies. However many benign conditions are also associated with leucoerythroblastosis such as hemolytic anaemia, marked infections and congestive cardiac failure, etc. So the study was performed to determine the various causes of leucoerythroblastic blood picture on bone marrow examination. The current retrospective diagnostic analytical study was performed in the hematology section of post graduate department of pathology over a period of one year. 80 patients with leucoerythroblastic picture on peripheral blood film (PBF), who were subjected to bone marrow aspiration and/or biopsy were included in the study. The findings were documented on a predefined performa and results tabulated.Majority of cases were seen in 21-30 years age group (25%) with male to female ratio of 1.1:1. Non-neoplastic disorders accounted for majority of cases (65%) while neoplastic lesions were seen in 35% cases. Megaloblastic anaemia was the commonest neo-neoplastic etiology while acute leukemia was the commonest neoplastic disorder in the present study.Leucoerythroblastosis represents disordered marrow function and is reflected in PBF. Bone marrow aspiration and biopsy help in establishing early diagnosis and management of the underlying condition.

show abstract

Section: Discussionmentioning

confidence: 55%

Role of bone marrow aspiration and biopsy in evaluation of leucoerythroblastic blood picture

Sharma

Hans²,

Naz³

2022

PJMS

View full text Add to dashboard Cite

show abstract

Systematic review about etiologic association to the leukoerythroblastic reaction

Calvache

Faulhaber

2020

Int J Lab Hematology

View full text Add to dashboard Cite

Background and purpose Leukoerythroblastic reaction (LER) is characterized by the presence of immature erythroid cells and myeloid precursors (metamyelocytes, myelocytes, promyelocytes, myeloblasts, and blasts) as well as, exclusively in myelofibrotic disorders, teardrop cells in the peripheral blood (J Pathol Bacteriol, 42, 1936, 541; Semaine Med, 22, 1902, 373). Research on how to interpret LER and its meaning in clinical practice is scarce, and there is no consensus on the diagnostic criteria. We summarize the current evidence with the aim of clarifying the knowledge on this subject. Methods We conducted a comprehensive search of the PubMed‐MEDLINE, EMBASE and ELSEVIER databases, the Cochrane Library, Google Scholar, and medical journals to identify relevant papers. Results Our search identified 425 papers, of which, 35 (11 trials and 24 case reports) ultimately met the inclusion criteria. These showed two principal groups of diseases associated with leukoerythroblastosis (LEB), corresponding to solid and hematological malignancies. The other etiologies, in order of frequency, were hemolytic diseases, infection, and others, while hemorrhage was only reported in the trials group. Conclusion The literature on LER is scarce and heterogeneous. The etiological factors of LER are diverse, and its presence in malignant disease is an indicator of disease progression and an adverse prognosis suggesting poor survival. In those cases where LER had neither hematological nor solid neoplasms, its manifestation, prognosis and its impact on our daily clinical practice are unknown.

show abstract

A Clinico-Hematological Study of Cases of Leucoerythroblastic Reaction

Cited by 2 publications

References 6 publications

Role of bone marrow aspiration and biopsy in evaluation of leucoerythroblastic blood picture

Role of bone marrow aspiration and biopsy in evaluation of leucoerythroblastic blood picture

Systematic review about etiologic association to the leukoerythroblastic reaction

Contact Info

Product

Resources

About