A Clinician’s Guide to Topical Retinoids

Motamedi, Melika; Chehade, Ahmad; Sanghera, Ravina; Grewal, Parbeer

doi:10.1177/12034754211035091

Cited by 27 publications

(54 citation statements)

References 30 publications

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“…Topical application of retinoids or their derivatives are also used to improve acne by normalizing abnormal desquamation; however, these compounds also induce skin dryness. 31 In contract, transcutaneous application of CO 2 decreased acne without changing sebum secretion and did not cause skin dryness. This analysis about changes in keratinization caused by transcutaneous application of CO 2 on the skin with acne symptoms might be needed for the confirmation.…”

Section: Discussionmentioning

confidence: 91%

“…Thus, these results may indicate that improvements in keratinization is crucial factor for decrease the acne with mild acne symptoms. Topical application of retinoids or their derivatives are also used to improve acne by normalizing abnormal desquamation; however, these compounds also induce skin dryness 31 . In contract, transcutaneous application of CO 2 decreased acne without changing sebum secretion and did not cause skin dryness.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of the continuous use of a lotion with carbon dioxide on male subjects with mild acne

Kiyozuka

Kajiyama

Ootsuki

et al. 2022

J of Cosmetic Dermatology

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Acne is a common skin disease of teenagers but it can occur in most age groups 1 and many adults are bothered with acne. Acne involves seborrheic areas of the face and results from the obstruction of hair follicles followed by inflammation. The key pathogenic factors that play important roles in the development of acne are the following four major factors: androgen-dependent sebogenesis, hyperkeratinization of the infundibulum, Cutibacterium acnes (C. acnes) colonization, and inflammation. 2

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Efficacy of the continuous use of a lotion with carbon dioxide on male subjects with mild acne

Kiyozuka

Kajiyama

Ootsuki

et al. 2022

J of Cosmetic Dermatology

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“…In addition to their anti-inflammatory properties, topical retinoids prevent follicular blockage by accelerating the shedding of corneocytes, making way for new cell growth underneath. Common topical retinoids include tretinoin, adapalene, and tazarotene [ 138 ]. On the other hand, benzoyl peroxide (BP) also possesses keratinolytic and anti-inflammatory properties along with bactericidal properties against P. acnes , which is mainly attributed to the generation of reactive oxygen species (ROS) [ 139 ].…”

Section: Topical Application Of Pnps For Treatment Of Skin Diseasesmentioning

confidence: 99%

Polymeric Nanoparticles as Tunable Nanocarriers for Targeted Delivery of Drugs to Skin Tissues for Treatment of Topical Skin Diseases

et al. 2023

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The topical route is the most appropriate route for the targeted delivery of drugs to skin tissues for the treatment of local skin diseases; however, the stratum corneum (SC), the foremost layer of the skin, acts as a major barrier. Numerous passive and active drug delivery techniques have been exploited to overcome this barrier; however, these modalities are associated with several detrimental effects which restrict their clinical applicability. Alternatively, nanotechnology-aided interventions have been extensively investigated for the topical administration of a wide range of therapeutics. In this review, we have mainly focused on the biopharmaceutical significance of polymeric nanoparticles (PNPs) (made from natural polymers) for the treatment of various topical skin diseases such as psoriasis, atopic dermatitis (AD), skin infection, skin cancer, acute-to-chronic wounds, and acne. The encapsulation of drug(s) into the inner core or adsorption onto the shell of PNPs has shown a marked improvement in their physicochemical properties, avoiding premature degradation and controlling the release kinetics, permeation through the SC, and retention in the skin layers. Furthermore, functionalization techniques such as PEGylation, conjugation with targeting ligand, and pH/thermo-responsiveness have shown further success in optimizing the therapeutic efficacy of PNPs for the treatment of skin diseases. Despite enormous progress in the development of PNPs, their clinical translation is still lacking, which could be a potential future perspective for researchers working in this field.

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“…Currently, second-generation retinoids are not used as active ingredients in formulations for topical application [ 145 ].…”

Section: Clinical Evidencementioning

confidence: 99%

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Milosheska¹,

Roškar

2022

Adv Ther

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Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

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A Clinician’s Guide to Topical Retinoids

Cited by 27 publications

References 30 publications

Efficacy of the continuous use of a lotion with carbon dioxide on male subjects with mild acne

Efficacy of the continuous use of a lotion with carbon dioxide on male subjects with mild acne

Polymeric Nanoparticles as Tunable Nanocarriers for Targeted Delivery of Drugs to Skin Tissues for Treatment of Topical Skin Diseases

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

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