A clinically useful and biologically informative genomic classifier for papillary thyroid cancer
Steven Craig,
Cynthia Stretch,
Farshad Farshidfar
et al.
Abstract:Clinical management of papillary thyroid cancer depends on estimations of prognosis. Standard care, which relies on prognostication based on clinicopathologic features, is inaccurate. We applied a machine learning algorithm (HighLifeR) to 502 cases annotated by The Cancer Genome Atlas Project to derive an accurate molecular prognostic classifier. Unsupervised analysis of the 82 genes that were most closely associated with recurrence after surgery enabled the identification of three unique molecular subtypes. O… Show more
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