A Clinical Trial with Nalidixic Acid on 22 Acute and Chronic Urinary Tract Infections with Follow-Up for 1–5 Months

Misra, G. C.; Willcox, M.

doi:10.1136/pgmj.41.478.508

Postgraduate Medical Journal

1965

DOI: 10.1136/pgmj.41.478.508

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A Clinical Trial with Nalidixic Acid on 22 Acute and Chronic Urinary Tract Infections with Follow-Up for 1–5 Months

G. C. Misra¹,

M. Willcox²

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Cited by 3 publications

References 15 publications

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Pharmacokinetics of Nalidixic Acid in Old and Young Volunteers

Barbeau

Bélanger

1982

The Journal of Clinical Pharma

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Plasma levels of active naphthyridine were measured in healthy old (mean age 77.3 years) and young (mean age 25.4 years) subjects following oral administration of 1 Gm nalidixic acid. The plasma levels of active naphthyridine, i.e., nalidixic acid and its metabolite 7-hydroxynalidixic acid, were generally higher in the old group, particularly in the elimination phase. Significant variations in the pharmacokinetic parameters were obtained between the two groups of volunteers. The plasma half-life of active naphthyridine averaged 11.5 hours in old subjects and 2.7 hours in the younger group. Diminished renal function in the geriatric group may explain the slower elimination of the drug in the old subjects. The mean values of the other parameters calculated were: apparent volume of distribution, 0.55 (old) and 0.47 (young) liter/kg body weight; area under the curve, 327.7 (old) and 156.3 (young) micrograms/ml x hr; total body clearance 2.9 (old) and 8.3 (young) liters/hr; absorption rate constant, 0.29 (old) and 0.52 (young) hr. -1

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Pharmacokinetics of Nalidixic Acid in Old and Young Volunteers

Barbeau

Bélanger

1982

The Journal of Clinical Pharma

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Experimental spectroscopic (FTIR, FT-Raman, FT-NMR, UV–Visible) and DFT studies of 1-ethyl-1,4-dihydro-7-methyl-4oxo-1,8 napthyridine-3-carboxylic acids

Muthu

Porchelvi²

2013

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Bacteriologic and Pharmacodynamic Aspects of Nalidixic Acid

Harrison

Cox

1970

Journal of Urology

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A Clinical Trial with Nalidixic Acid on 22 Acute and Chronic Urinary Tract Infections with Follow-Up for 1–5 Months

Cited by 3 publications

References 15 publications

Pharmacokinetics of Nalidixic Acid in Old and Young Volunteers

Pharmacokinetics of Nalidixic Acid in Old and Young Volunteers

Experimental spectroscopic (FTIR, FT-Raman, FT-NMR, UV–Visible) and DFT studies of 1-ethyl-1,4-dihydro-7-methyl-4oxo-1,8 napthyridine-3-carboxylic acids

Bacteriologic and Pharmacodynamic Aspects of Nalidixic Acid

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