A clinical trial with a novel collagen dermal substitute for wound healing in burn patients

Abstract

Biomechanical properties of new dermal replacement were very similar than commercial products. Also this replacement can be used for skin regeneration for burn wounds. Therefore, we suggest that new dermal replacement can be used in the medical field.

Factors affecting thermal stability of collagen from the aspects of extraction, processing and modification

“…Triple helix establishes excellent characteristics for collagen, such as fiber-forming property, biocompatibility and bioactivity, which make collagen widely used in leather industry, tissue engineering [12], pharmaceuticals [13], foods [14] and cosmetics [15]. Native collagen has been molded into different forms to adequate to the specific demands: fibers for skin in leather industry, members for sausage casing in foods, aqueous solution for a standard raw material in cosmetic formulations and gels, pellets, nanoparticles, scaffolds, sponges for biomedicines [16].…”

Epithelial differentiation of human adipose-derived stem cells (hASCs) undergoing three-dimensional (3D) cultivation with collagen sponge scaffold (CSS) via an indirect co-culture strategy

“…Otherwise, differentiation of stem cells depends on the "niche," including diffusible paracrine effects, ECM, and cellular and mechanical factors [21,26,27,56], and most studies are based solely on 2D induction culture missing the biophysical microenvironments of the ECM. In contrast, 3D system using scaffolds (with interconnected pores) which mimic the structure and function of ECM proteins not only promotes cell adhesion, cell-biomaterial interactions, and cell proliferation [10,38,39], but also facilitates differentiation in skin regeneration [10,57,58].…”

“…With the development of tissue engineering technology, many skin scaffolds (termed as skin substitutes or artificial dermis) have been conceived as skin wound dressings [6] and applied clinically for eventual scar-free wound healing, including Pelnac® (Japan) [10], Integra® (USA) [10], and Lando® (China) [35] [36,37]. Currently, artificial dermis commercially available mainly consists of collagen sponge scaffolds (CSSs) with multiple desirable characteristics (such as biocompatibility, an interconnected pore structure, and sufficient biodegradability) [10,38,39], which are utilized as templates to promote fibroblasts and endothelial cells to proliferate [40], migrate and mature into scaffolds, and promote dermal regeneration and neovascularization, significantly reducing contracture and scar formation [41][42][43].…”

Applications of nanomaterials in tissue engineering

“…It is also used for dermal replacement of burns and other wounds, and many in vivo and in vitro biological evaluations have been carried out. 24,25 PLGA is another synthetic polymer with good biodegradability and biocompatibility. It can be used to load various types of drugs such as hydrophilic or hydrophobic, small or large molecule medicine.…”