A Clinical Trial of Hydroxyethylrutosides in the Treatment of Haemorrhoids of Pregnancy

Abstract

The safety and efficacy of 500 mg O-(beta-hydroxyethyl)rutosides given orally twice daily in the treatment of 97 patients with first-, second-, or third-degree haemorrhoids were investigated in a double-blind, randomized placebo-controlled trial. The rutosides produced a significant (P less than 0.001) improvement in patient-assessed subjective symptoms (pain, bleeding, exudation and pruritus) compared with placebo. There was also a significant (P less than 0.001) improvement in clinician-assessed subjective and objective signs (bleeding, inflammation and dilatation of the haemorrhoidal plexus) after 2 and 4 weeks' treatment compared with placebo. There were three mild, transient side-effects reported in the active treatment group and no drug-related problems in the pregnancy or delivery were observed. The results suggest that O-(beta-hydroxyethyl)rutosides provide a safe and effective treatment for women with haemorrhoids of pregnancy.

Troxerutin, a plant flavonoid, protects cells against oxidative stress-induced cell death through radical scavenging mechanism

“…It possesses antierythrocytic, anti-thrombotic, and anti-fibrinolytic, properties (Liu, Ma & Lou, 2010). Its effectiveness and safety have been evaluated in elderly patients (Marhic, 1991;Maurya, Balakrishnan, Salvi & Nair, 2005), as well as in pregnant women, with good results (Wijayanegara, Mose, Achmad, Sobarna & Permadi, 1992;Maurya et al, 2005). The radioprotective efficacy of the TRX has been demonstrated in our laboratory.…”

The Effect of Oral Psyllium Herbal Laxative Powder in Prevention of Hemorrhoids and Anal Fissure during Pregnancy, a Randomized Double Blind Clinical Trial

“…In another study in Indonesia, the effect of Hydroxy ethyl rothoside in treatment of hemorrhoidal diseases during pregnancy was studied that shown pain, bleeding, secretion and itching (16). In another study in Italy, the effect of betahydroxy ethyl rothoside to treat hemorrhoidal diseases during pregnancy was studied and a considerable clinical recovery was noticed (17).…”

Traitement médical de la pathologie hémorroïdaire

“…D'autres substances (troxérutine, dérivés du Ginkgo biloba, hydroxyl-éthylrutosides) ont été comparées à la diosmine dans sa forme native sans différence significative d'efficacité sur les symptômes [14]. Ils n'ont pas d'effet secondaire remarquable, y compris pour la diosmine chez la femme enceinte [15,16], en dehors de rares cas de colites lymphocytaires [17]. La prescription de veinotoniques à long terme à titre préventif n'est pas justifiée, leur utilisation n'ayant pas été testée au-delà de trois mois [12].…”