A Clinical Study on the Antihypertensive Effect of Arotinolol

Lee, Ock Chan; Yoon, Seok Jin; Kim, Ji Hoon; Chang, Dae Kuk; Kim, Jong Pil; Kim, Kung Soo; Kim, Jeong Hyun; Im, Heon Kil; Lee, Bang Hun; Lee, Chung Kyun

doi:10.4070/kcj.1990.20.4.800

Cited by 2 publications

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“…Among the known array of organosulfur derivatives, thioethers are well‐acclaimed subsets due to their highly desirable pharmacologically relevant properties. Thioether derived drugs display antihypertensive, [5] antimicrobial, [6] antitumor, [7] fungicidal, [8] antiulcer [9] properties. Representative examples of bioactive thioether molecules are furnished in Figure 1 [10,11] …”

Section: Introductionmentioning

confidence: 99%

Catalyst‐Free Synthesis of Thioethers through C−N Bond Cleavage of Aminonaphthol/Aminophenol Derivatives

et al. 2022

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Readily available aminonaphthol/aminophenol derivatives were converted to the corresponding thioethers under catalyst‐free reaction conditions. Environmentally benign aqueous medium was utilized for the transformation of aminonaphthol derivatives to the corresponding thioethers under aerobic reaction conditions. Saturated brine solution was identified as a suitable medium for the synthesis of thioethers from aminophenol derivatives. Control experiments revealed that the nature of leaving group and reaction atmosphere plays a vital role in determining the yield of the products.

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Section: Introductionmentioning

confidence: 99%

Catalyst‐Free Synthesis of Thioethers through C−N Bond Cleavage of Aminonaphthol/Aminophenol Derivatives

et al. 2022

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The Clinical Effects of Losartan (Cozaar) on Hypertensive Patients

Jeong¹,

Park²,

Kim³

et al. 1998

Korean Circ J

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Background Losartan potassium, one of an orally active, selective type 1 angiotensin receptor blocker, has been introduced recently as an antihypertensive agent. Method Losartan, angiotensin receptor blocker, was administrated as an initial antihypertensive agent over 12 weeks in 30 patients 11 male, 19 female, 60.1 7.2 years with stage 1 to 3 hypertension in order to observe the clinical effects. Changes in quality of life, side effects, electrocardiogram and left ventricular function were also evaluated before and after losartan therapy. Results 1 After 12 weeks treatment with 50 to 100 mg of losartan, blood pressure was lowered markedly in 18 60% , moderately in 9 30% and mildly in 1 3% out of 30 patients studied. The average of blood pressures of the 30 subjects were systolic 159.0 13.2 mmHg and diastolic 100.7 9.4 mmHg before treatment, which were lowered to 130.7 15.6 and 85.9 9.1 mmHg respectively after 12 weeks p 0.005 . 2 Heart rates were not changed with losartan. 3 Quality of life including general well-being, physical symptom, sleep and sexual dysfunction improved markedly in 2 7% and slightly in 17 57% out of 30 subjects. 4 Laboratory findings revealed no significant changes. 5 In electrocardiographic and echocardiographic follow-up 1 patient with ST-T abnormality and 2 patients with mild LV systolic dysfunction improved to normal. 6 Undesirable side effects were observed in 2 cases with dizziness, 1 dry cough, 1 skin rash, 1 leg edema and 1 epigastric discomfort, among whom one with dizziness stopped losartan. 7 In the final clinical assessment according to the scores of hypotensive effect, quality of life, LV function and side effect, losartan was very useful in 3 10% , useful in 18 60% and slightly useful in 3 10% out of 30 hypertensive patients. Conclusion Losartan can be used as an effective initial agent for the treatment of hypertension of various severities with the improvement of quality of life and low side effects.

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A Clinical Study on the Antihypertensive Effect of Arotinolol

Cited by 2 publications

References 0 publications

Catalyst‐Free Synthesis of Thioethers through C−N Bond Cleavage of Aminonaphthol/Aminophenol Derivatives

Catalyst‐Free Synthesis of Thioethers through C−N Bond Cleavage of Aminonaphthol/Aminophenol Derivatives

The Clinical Effects of Losartan (Cozaar) on Hypertensive Patients

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