A Clinical Study of the Human Lens with a Dynamic Light Scattering Device

Datiles, Manuel B.; Ansari, Rafat R.; Reed, George F.

doi:10.1006/exer.2001.1106

Cited by 31 publications

(31 citation statements)

References 15 publications

(32 reference statements)

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“…Dynamic light scattering (DLS) uses backscatter from a low energy laser beam to determine information about particle size, shape, movement and interactions. The technique is applicable to all eye tissues and has already shown promise for early cataract detection by monitoring the α-crystallin proteins that prevent protein aggregation in the lens [111][112][113].…”

Section: (Figure 3)mentioning

confidence: 99%

Ocular Biomarkers for Early Detection of Alzheimer's Disease

Frost

Martins

Kanagasingam

2010

JAD

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Alzheimer's disease (AD) is the most common form of dementia and is characterized clinically by a progressive decline in memory, learning and executive function and neuropathologically by the presence of cerebral amyloid deposits. Despite a century of research, there is still no cure or conclusive pre-mortem diagnosis for the disease. A number of symptom-modifying drugs for AD have been developed, but their efficacy is minimal and short-lived. AD cognitive symptoms arise only after significant, irreversible neural deterioration has occurred, hence there is an urgent need to detect AD early, before the onset of cognitive symptoms. An accurate, early diagnostic test for AD would enable current and future treatments to be more effective, as well as contribute to the development of new treatments.While most AD related pathology occurs in the brain, the disease has also been reported to affect the eye, which is more accessible for imaging than the brain. AD-related proteins exist in the normal human eye and may produce ocular pathology in AD. There is some homology between the retinal and cerebral vasculatures and the retina also contains nerve cells and fibers that form a sensory extension of the brain. The eye is the only place in the body where vasculature or neural tissue is available for non-invasive optical imaging. This article presents a review of current literature on ocular morphology in AD and discusses the potential for an ocular based screening test for AD.

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Section: (Figure 3)mentioning

confidence: 99%

Ocular Biomarkers for Early Detection of Alzheimer's Disease

Frost

Martins

Kanagasingam

2010

JAD

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“…Ansari 36 recently authored a comprehensive overview of ophthalmic applications of DLS. These studies and others demonstrated the sensitivity and accuracy of this technology in evaluating lens 37,38 and vitreous 39, 40 macromolecules. To perform DLS studies in vitreous, the laser is focused into the specimen, and back-scattered light from a 50μm 3 volume of vitreous is captured by the probe.…”

Section: Dynamic Light Scatteringmentioning

confidence: 78%

Molecular biology of pharmacologic vitreolysis

Sebag¹

2006

American Journal of Ophthalmology

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“…Exposing cornea with laser power levels of few microwatts at near infrared wavelengths in humans is very safe since the pupil dilation is not required and the focal spot rapidly defocuses past the cornea. A new instrument integrating DLS and videokeratoscopy built at NASA and already in use for cataract studies 6 at NEI/NIH (Datiles et al, 2002) will soon be used for monitoring patients before and after LASIK surgeries.…”

Section: Resultsmentioning

confidence: 99%

“…We used a DLS fiber optic probe described elsewhere. [4][5][6][7] The VK (Keratron corneal analyzer, model Optikon 2000, Roma, Italy) was performed to obtain a refractive power topographical map of the corneal surface. The map shows corneal regions in a 3 mm central zone in which the refractive power remains constant.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…McLeod 3 (2001), in his editorial, stresses the need for new diagnostic capabilities to better evaluate current refractive surgery outcomes. Ansari and Datiles 4 (1999), Sebag et al 5 (1999), Datiles et al 6 (2002), and Ansari et al, 7 (2002) have used a compact fiber optic DLS device, initially developed at NASA for fluid physics experiments in space, to detect early lens and vitreous abnormalities, e.g., cataract and diabetic vitreopathy by evaluating the molecular structures of these tissues and fluids. [4][5][6][7] Fankhauser II and colleagues in an ARVO abstract 8 (1997) suggested the use of DLS in detecting wound healing complications after excimer laser surgery.…”

Section: Introductionmentioning

confidence: 99%

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