A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Zhang, Chenglong; Shao, Shurong; Ye, Chaohui; Jiang, Bengui

doi:10.1155/2021/8037459

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Correlation analysis of reproductive hormone levels with sleep indicators assessed objectively and subjectively showed that the faster the FSH changed, the longer the sleep duration, and the poorer the sleep quality all were associated with poorer self-reported PSQI [33]. Estradiol valerate has been shown to improve serum sex hormone levels, sleep disturbances, negative mood and quality of life in patients with perimenopausal syndrome [34]. In this study, melatonin treatment significantly improved the FSH, LH and E2 levels in patients with perimenopausal sleep disorders, but had no significant effect on P, T and PRL.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Alleviates Perimenopausal Sleep Disorders by Regulating the Expression of MTNR1A and Hormone Level: A Retrospective Study

Chen¹,

Zhang²,

Zhang³

2023

Clin. Exp. Obstet. Gynecol.

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Background: Sleep disorder, frequently observed among perimenopausal women, decreases quality of life. Melatonin is reported to ameliorate circadian imbalances and thus can be employed as a treatment for perimenopausal sleep disorder patients. We attempted to clarify whether and how melatonin affects perimenopausal sleep disorders. Methods: Study patients consisted of 120 perimenopausal women divided into 3 groups: (i) perimenopausal women without sleep disorder (n = 60); (ii) those with sleep disorder but without melatonin treatment (n = 30); and (iii) those with sleep disorder with melatonin treatment (n = 30). During the period March 2019 to December 2019, the following data was collected and analyzed: Pittsburgh Sleep Quality index (PSQI) score, sex hormones, melatonin, melatonin 1A receptor (MTNR1A), protein kinase A (PKA), extracellular signal-regulated kinase 1/2 (ERK1/2), phosphorylation-PKA (p-PKA), and p-ERK1/2 levels. We compared these data between the groups. Results: Melatonin administration showed the following in female patients with postmenopausal sleep disorder: (1) significantly decreased the PSQI scores, (2) up-regulated melatonin levels and MTNR1A protein expression, (3) promoted the phosphorylation pathway of the PKA-ERK1/2 pathway in peripheral blood, and (4) significantly improved follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) levels. Melatonin administration had no significant effect on progesterone (P), testosterone (T) or prolactin (PRL). Conclusions: Melatonin therapy alleviated perimenopausal sleep disorders. Up-regulation of MTNR1A expression and improvement of the hormone balance were also observed, which may the reason for the observed sleep-disorder-amelioration. Melatonin has the potential to be a useful option for perimenopausal sleep disorders.

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Section: Discussionmentioning

confidence: 99%

Melatonin Alleviates Perimenopausal Sleep Disorders by Regulating the Expression of MTNR1A and Hormone Level: A Retrospective Study

Chen¹,

Zhang²,

Zhang³

2023

Clin. Exp. Obstet. Gynecol.

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“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”

mentioning

confidence: 99%

Retracted: A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

and Alternative Medicine

2023

Evidence-Based Complementary and Alternative Medicine

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Analysis of the Effects of the WeChat Health Management Platform on the Self-care Ability and Quality of Life of Patients with Liver Cancer Undergoing Interventional Therapy

Li,

Yuan,

Chen

et al. 2023

Hepat Mon

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Background: With the popularity of WeChat, Internet-based nursing approaches are gradually being applied to disease care, as they can better meet nursing requirements. Objectives: To explore the impact of the WeChat health management platform on the self-care ability and quality of life of patients with liver cancer undergoing interventional therapy Methods: A total of 82 patients with liver cancer who underwent interventional therapy were selected from January 2020 to January 2021 and randomly divided into the observation (n = 41) and control (n = 41) groups. The control group received routine nursing measures, while the observation group received the new nursing mode based on the WeChat health management platform. The WeChat health management platform can help patients develop health education plans, remind them of follow-up appointments, promote knowledge about nursing measures for liver cancer interventional therapies, provide feedback on medication use to doctors, and strengthen doctor–patient communication. The self-care ability and quality of life of the two groups of patients were compared before and after the intervention. Results: After the intervention, the Hamilton Anxiety Scale (HAMA) and Hamilton Rating Scale for Depression (HAMD) scores were lower in the patients of the observation group than those in the control group, indicating an improvement in the adverse moods and quality of life of patients in the observation group. Also, the psychological, physical, and social functions and overall health scores of patients in the observation group were higher than those in the control group (all P-values < 0.05). Conclusions: The WeChat health management platform could improve the self-care ability of liver cancer patients undergoing interventional therapy and their mood and quality of life, which is worthy of clinical reference.

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A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Cited by 3 publications

References 25 publications

Melatonin Alleviates Perimenopausal Sleep Disorders by Regulating the Expression of MTNR1A and Hormone Level: A Retrospective Study

Melatonin Alleviates Perimenopausal Sleep Disorders by Regulating the Expression of MTNR1A and Hormone Level: A Retrospective Study

Retracted: A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Analysis of the Effects of the WeChat Health Management Platform on the Self-care Ability and Quality of Life of Patients with Liver Cancer Undergoing Interventional Therapy

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