A Clinical Study of the Comparative Effect of Nitrogen Mustard and DON in Patients With Bronchogenic Carcinoma, Hodgkin's Disease, Lymphosarcoma, and Melanoma2

Krantz, Simon; Rivers, Shirley L.; Dwight, Richard W.; Corbus, Howard F.; Wolf, Julius; Green, Ira; Spear, Paul W.; Imperato, L; Löbe, S; Whittington, Richard; Rumball, John M.; Márquez, Antonia; Cables, Coral; Chernoff, Amoz I.; Misra, Dwijenora K.; Sullivan, Robert D.; Miller, Edward B.; Dietrich, Frank; Plitman, Gerald I.; Close, Henry P.; McCracken, Stewart; Glushien, Arthur S.; Rucknagel, Donald L.; Li, C. C.; Kodlin, Dankward

doi:10.1093/jnci/22.2.433

Cited by 20 publications

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Single-Agent Therapy for Hodgkin's Disease

Carter¹

1973

Arch Intern Med

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We have reviewed existing data on single drugs in the chemotherapy of Hodgkin's disease in order to place in perspective the recent results with regimens employing combinations of drugs. Combination chemotherapy, by historical comparison with single-drug therapy, is clearly superior in the induction of complete remission of disease. However, many single agents, particularly those in the antimetabolite and antibiotic classes of antitumor drugs, have been evaluated only minimally and may yet play important roles in the design of future combination therapies. rapidity of effect, and his prejudice

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Single-Agent Therapy for Hodgkin's Disease

Carter¹

1973

Arch Intern Med

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Acute leukemia in the adult male.I. Comparative effect of 6-mercaptopurine and 6-chloropurine

Whittington¹,

Rivers²,

Doyle³

et al. 1963

Cancer

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The chemotherapy of Hodgkin's disease.Past experiences and future directions

DeVita¹,

Lewis²,

Rozencweig³

et al. 1978

Cancer

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From the standpoint of chemotherapy, the first progress in the treatment of Hodgkin's disease was the identification of the activity of nitrogen mustard in the 1940's. The initial antitumor effect of the drug created a great excitement. However, when all patients later relapsed, there was subsequent dejection and skepticism about the utility of drug therapy. Fortunately, in the 1950's and 1960's, the development of other effective agents (vinca alkaloids, corticosteroids, and methylhydrazines) in conjunction with the elucidation of the principles of combination chemotherapy led to a marked increase in the antitumor response rate of patients with Hodgkin's disease. The value of many of these drug combinations remains under study. Nonetheless, approximately 75% of all patients with advanced Hodgkin's disease treated today with combination chemotherapy can achieve a complete remission. In addition, over half of these remain disease-free long enough to be considered cured. The development of effective treatment, both local (radiotherapy) and systemic (MOPP chemotherapy), has given the clinical investigator the tools to complete, in the 1970's, the therapeutic experiments necessary to refine both the interrelationship between the treatments and their impact upon the natural history of Hodgkin's disease.

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A Clinical Study of the Comparative Effect of Nitrogen Mustard and DON in Patients With Bronchogenic Carcinoma, Hodgkin's Disease, Lymphosarcoma, and Melanoma2

Cited by 20 publications

References 0 publications

Single-Agent Therapy for Hodgkin's Disease

Single-Agent Therapy for Hodgkin's Disease

Acute leukemia in the adult male.I. Comparative effect of 6-mercaptopurine and 6-chloropurine

The chemotherapy of Hodgkin's disease.Past experiences and future directions

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