A clinical study of serum magnesium concentrations during anaesthesia and cardiopulmonary bypass

Calverley, R. K.; Jenkins, Leonard C.; Griffiths, John C.; Sarudny, K.

doi:10.1007/bf03026212

Cited by 12 publications

(2 citation statements)

References 26 publications

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“…Direct muscle stimulation of the orbicularis oculi muscle may have occurred, which would also result in a relative overdose. Third, alterations in the pharmacokinetic and pharmacodynamic properties of pancuronium, which are induced by CPB, can contribute to postoperative residual muscle weakness (12)(13)(14)(15)(16). Increased sensitivity of muscles to pancuronium has been shown to persist into the post-CPB period (17).…”

Section: Discussionmentioning

confidence: 98%

Recovery of Neuromuscular Function After Cardiac Surgery: Pancuronium Versus Rocuronium

Murphy¹,

Szokol²,

Marymont³

et al. 2003

Anesthesia & Analgesia

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Section: Discussionmentioning

confidence: 98%

Recovery of Neuromuscular Function After Cardiac Surgery: Pancuronium Versus Rocuronium

Murphy¹,

Szokol²,

Marymont³

et al. 2003

Anesthesia & Analgesia

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“…

three decades [1][2][3][4][5][6][7][8][9][10][11]. In addition, it is shown that hypomagnesemia following cardiac surgery is associated with an increase in the incidence of dysrhythmia, and Mg administration could contribute to fewer postoperative dysrhythmias [5][6][7] or better myocardial recovery [7].

…”

mentioning

confidence: 98%

Changes in plasma total and ionized magnesium concentrations and factors affecting magnesium concentrations during cardiac surgery

et al. 2004

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The purpose of this study was to measure blood total and ionized magnesium concentrations ([TMg] and [Mg(2+)], respectively) and to investigate factors that might be affecting their changes during cardiac surgery using hypothermic cardiopulmonary bypass. Eight patients were examined. All the patients received diuretics and predeposited autologous blood during surgery. No drugs containing Mg(2+) were administered. Nine blood samples and eight urine samples were collected from the pre-induction period to the end of surgery. Hematocrit, [TMg], [Mg(2+)], plasma concentrations of calcium ([Ca(2+)]), creatinine, parathyroid hormone (PTH), urinary concentrations of TMg, and creatinine were measured, and the fractional excretion of Mg (FEMg) was calculated. Both [TMg] and [Mg(2+)] decreased significantly in the prebypass period and remained significantly depressed thereafter. The ionized fraction of magnesium ([Mg(2+)]/[TMg]) was decreased during the postbypass period. Hematocrit decreased significantly from the prebypass period, and FEMg increased significantly after aortic cross-clamping. In conclusion, hemodilution and renal loss were main causes of hypomagnesemia, and citrate in predeposited autologous blood may contribute to the decrease in [Mg(2+)]/[TMg] in the postbypass period. These results suggest that magnesium supplementation under close monitoring of [Mg(2+)] should be required during cardiac surgery.

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Magnesium Administration and Dysrhythmias After Cardiac Surgery

England

Gordon²,

Salem³

et al. 1992

JAMA

203

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A clinical study of serum magnesium concentrations during anaesthesia and cardiopulmonary bypass

Cited by 12 publications

References 26 publications

Recovery of Neuromuscular Function After Cardiac Surgery: Pancuronium Versus Rocuronium

Recovery of Neuromuscular Function After Cardiac Surgery: Pancuronium Versus Rocuronium

Changes in plasma total and ionized magnesium concentrations and factors affecting magnesium concentrations during cardiac surgery

Magnesium Administration and Dysrhythmias After Cardiac Surgery

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