A Clinical Study of Prognosis and Glucocorticoid Pulse Treatment in Patients with Acute Paraquat Intoxication

Tsai, Jen Pi; Lee, Ru Ping; Wang, Hsiu-Po; Fang, Te Chao; Hsu, Bang Gee

doi:10.1016/s1016-3190(09)60029-x

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…Seven articles included in this set which their results are summarized in Table 2 and supplementary Table 2. [2384344454647] Patients in HP group received conventional therapy and HP. Patients in HP in combination with other treatment group received conventional therapy, HP, and CVVH or continuous renal replacement therapy (CRRT) or CP or/and MP or Chinese medications Xuebijing (XBJ)/Ulinastatin.…”

Section: Resultsmentioning

confidence: 99%

“…In three studies, CP/MP was the combination treatments with HP, with good effect on survival. [434647] In the study of Ghorbani et al ., the mortality rate of patients received HP/CP/MP was lower than those underwent HP only (25% vs. 60.9%).…”

Section: Discussionmentioning

confidence: 99%

“…in a case–control study showed that mortality rate was not significantly different between patients received HP and those received HP and MP. [43] In the Tsai study, CP was not administered for the patients which may be the reason. Wu et al .…”

Section: Discussionmentioning

confidence: 99%

“…[46] Of course, the time to performing HP and HP duration has not been mentioned in these two studies which may be the limitation of their studies. [4346] HP duration and early HP may have effects on more removing PQ from the body. The efficacy of MP/CP in reducing mortality has been reported in two previous meta-analyses.…”

Section: Discussionmentioning

confidence: 99%

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Does hemoperfusion in combination with other treatments reduce the mortality of patients with paraquat poisoning more than hemoperfusion alone: A systematic review with meta-analysis

et al. 2019

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Background: Paraquat (PQ) poisoning is a serious public health problem in many countries. In spite of different treatments, the mortality is still high. We performed a meta-analysis to see whether hemoperfusion (HP) in combination with other treatments reduces the mortality more than HP alone in patients with PQ poisoning. Materials and Methods: We searched EMBASE, PubMed, Google Scholar, ISI Web of Knowledge, Cochrane Central Register of Controlled Trials, Scopus, Springer, TRIP, ProQuest, and references of the included studies from January 2000 to August 2017. Two reviewers independently searched and extracted data. We measured I 2 to determine variance contributed by heterogeneity. To investigate the publication bias, Begg's and Egger's tests were used along with funnel plot analysis. Results: Ultimately 12 articles were included in the meta-analysis. Five articles compared HP with conventional therapy with a total of 1311 patients, and seven articles compared mortality of patients received HP versus those received HP in combination with an additional treatment. HP alone reduced the odds of death (odds ratio [OR] = 0.20; 95% confidence interval [CI]: 0.11–0.40, P < 0.0001) compared to conventional therapy. Furthermore, the odds of death was higher in HP group compared to those received HP in combination of additional treatments (OR = 1.24; 95% CI: 1.05–1.46, P = 0.01). Conclusion: The mortality was less in HP-treated group compared to those received only conventional therapy. Addition of other treatments with HP reduced the mortality more than HP alone.

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