A Clinical Study of Epileptic Children Treated by Ketogenic Diet

Talbot, Fritz B.; Metcalf, Kenneth M.; Moriarty, Margaret E.

doi:10.1056/nejm192701201960302

Cited by 29 publications

(5 citation statements)

References 3 publications

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“…Subjects were instructed to conform to either the classical KD (ketogenic ratio between 4:1 and 3:1) [ 11 , 12 ] or modified Atkins diet (MAD) (estimated ketogenic ratio between 1:1 and 3:1) [ 13 ]). (Dietary details are presented in Supplementary Table S2 ).…”

Section: Methodsmentioning

confidence: 99%

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Dietary-Induced Ketogenesis: Adults Are Not Children

et al. 2021

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There is increasing interest in the use of a ketogenic diet for various adult disorders; however, the ability of adults to generate ketones is unknown. Our goal was to challenge the hypothesis that there would be no difference between adults and children regarding their ability to enter ketosis. Methods: Two populations were studied, both treated with identical very low-carbohydrate high-fat diets: a retrospective series of children with epilepsy or/and metabolic disorders (2009–2016) and a prospective clinical trial of adults with glioblastoma. Dietary intake was assessed based upon written food diaries and 24-h dietary recall. Ketogenic ratio was calculated according to [grams of fat consumed]/[grams of carbohydrate and protein consumed]. Ketone levels (β-hydroxybutyrate) were measured in blood and/or urine. Results: A total of 168 encounters amongst 28 individuals were analyzed. Amongst both children and adults, ketone levels correlated with nutritional ketogenic ratio; however, the absolute ketone levels in adults were approximately one quarter of those seen in children. This difference was highly significant in a multivariate linear regression model, p < 0.0001. Conclusions: For diets with comparable ketogenic ratios, adults have lower blood ketone levels than children; consequently, high levels of nutritional ketosis are unobtainable in adults.

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Section: Methodsmentioning

confidence: 99%

“…Ketogenic ratio was calculated according to the formula: total fat intake (gram) divided by the sum of total protein intake (gram) and total carbohydrate intake (gram) [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

Dietary-Induced Ketogenesis: Adults Are Not Children

et al. 2021

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“…The interest in new application as status epilepticus is evidence by TC2 values of Nabbout et al 23 The limitations of bibliometric analysis primarily result from two factors; the applied search strategy: different search terms might yield different results, and the choice of citation database: only publications included can be retrieved, i.e. historical articles dated before 1930s [29][30][31][32][33][34][35] are not retrieved in Scopus.…”

Section: Interceptmentioning

confidence: 99%

A bibliometric study of scientific literature on the dietary therapies for epilepsy in Scopus

Morandi

Guido

Tagliabue

2014

Nutritional Neuroscience

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The overview of the literature on the dietary therapy of epilepsy evidences a growing interest in the field with a striking prevalence of clinical over basic science studies. The most cited clinical studies have validated the efficacy of the dietary therapies; the few studies on the mechanisms of action received a great number of citations. Bibliometric analysis measuring the trends and the impact of the scientific literature would help researchers to a best knowledge of this specific topic.

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“…The suggestion that a diet that is very high in fat and low in carbohydrate might mimic these fasting-induced metabolic changes and thus have benefit to individuals with epilepsy 3 led to the development of the ketogenic diet (KD) that is still used today. Other early studies reported effective use of this treatment in children [4][5][6][7][8] and adults 9 with epilepsy. Although interest in diet therapy diminished with the development of new anticonvulsant medications toward the end of the 1930s, more recently there has been a reversal of this trend with KD research and worldwide clinical use increasing significantly over the last 20 years.…”

Section: Introductionmentioning

confidence: 99%

Ketogenic dietary therapy for epilepsy and other disorders: current perspectives

Neal¹

2014

NDS

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The ketogenic diet (KD) is a high-fat, restricted-carbohydrate regime, originally designed to mimic metabolic responses to fasting and has been used since the 1920s as a treatment for epilepsy. Modified variants of the KD include the addition of medium-chain triglyceride and less-restrictive modified Atkins and low glycemic index protocols. Scientifically proven as treatment for intractable seizures in children, these ketone-generating diets are increasingly also being used in adults. They are the treatment of choice in glucose transporter type 1 deficiency syndrome and pyruvate dehydrogenase deficiency. Evidence for the potential of KD therapy to be included within the treatment options for cancer and neurodegenerative disorders is more limited, albeit an exciting area of research with future clinical potential. This review discusses the key aspects of KD therapy, including the efficacy of treatments and clinical implementation. The importance of appropriate initiation, adequate clinical supervision, regular monitoring, and assessment of nutritional needs is highlighted.

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A Clinical Study of Epileptic Children Treated by Ketogenic Diet

Cited by 29 publications

References 3 publications

Dietary-Induced Ketogenesis: Adults Are Not Children

Dietary-Induced Ketogenesis: Adults Are Not Children

A bibliometric study of scientific literature on the dietary therapies for epilepsy in Scopus

Ketogenic dietary therapy for epilepsy and other disorders: current perspectives

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