A clinical study of efficacy of garlic extract versus cryotherapy in the treatment of male genital wart

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

“…The increasing number of pre-clinical studies on this topic indicates the necessity to optimize garlic's clinical evaluation. A number of clinical trials have shown antiviral effects of garlic against viral cold and flu infections ( Hiltunen et al, 2007 ; Josling, 2001 ; Nantz et al, 2012 ; Percival, 2016 ), acute respiratory viral infections ( Andrianova et al, 2003 ) and immune actions against recalcitrant multiple common warts (RMCW) ( Kenawy et al, 2014 ; Mousavi et al, 2018 ) ( Table 5 ).…”

“…Although, it is reported that the immunotherapy is associated with a stimulation of immune response against HPV (mediated by different cytokines), the results indicated wart regression might be associated with indirect immunomodulation, as well as an interplay between different cytokines other than TNF-α ( Kenawy et al, 2014 ). Garlic extract proved to be effective in the complete eradication of cutaneous warts ( Lipke, 2006 ) and recently Mousavi et al, 2018 conducted another RCT to evaluate the effect of garlic compared with cryotherapy (liquid nitrogen) on male genital warts. Both groups, the cryotherapy and active group (10% garlic extract) consisted of 33 men who all had at least one genital wart on both sides of the genital region.…”

“…Both groups, the cryotherapy and active group (10% garlic extract) consisted of 33 men who all had at least one genital wart on both sides of the genital region. GE (10%) was applied on the left side warts and cryotherapy (on right side warts for 56 days ( Mousavi et al, 2018 ). Significant complete eradication of male genital warts (about 70%) was observed in the active (10% GE) group with results being comparable to cryotherapy (78% eradication).…”

“… Lee et al (2012) one placebo group and three escalating dose groups (2, 3, or 6 study drug capsules a day) one placebo capsule/day for 42 days with 7 days follow-up RCTs with two parallel groups; 52 subjects including 26 in each group of frequent travelers with average age 38 yr Cellulose only or Cellulose and powdered garlic extract combined One sniff (cellulose and PGE combined) in each nostril every day for 56 days and if an infection developed, participants instructed to take up to 3 sniffs per nostril on each day until infection reduced One sniff (cellulose only) in each nostril every day for 56 days and if an infection developed take 3 sniffs per nostril on each day until infection reduced Active group (cellulose and PGE combined) (n = 26) and placebo (cellulose only) (n = 26) Five point scale to examine health and number of infections, day of recovery start and day of fully recovery, variety of symptoms in their daily diary Hiltunen et al (2007) one placebo group (n = 26) and one active group (n = 26) RCTs with two parallel groups of 35 subjects and all male; 33 subjects; all clinically diagnosed genital warts who had more than two warts on both sides of genital region enrolled in the study with mean age 33 yr Garlic extract (10%) in polyethylene glycol application on warts Garlic extract (10%) on left side warts (active group) and cryotherpary with liquid nitrogen on right side warts (placebo gropu) for 56 days Placebo, cryotherpary with liquid nitrogen on right side warts twice a day for 56 days Garlic extract (10%) in polyethylene glycol on left side warts by cotton swab twice a day for 56 Size and number of warts lesions reduced. Mousavi et al (2018) one placebo group and one active group RCTs with two parallel groups of 3° subjects and all children; 30 subjects; all children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin with age 3–15 yrs Inosine pranobex (50 mg/kg) as active Inosine pranobex Control group, Inosine pranobex Clinical and immunological investigations before and after the treatment (counted for CD3 ...…”

Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation

“…Garlic preparations also have shown to be effective in male genital warts; indeed, the application of a 10% garlic extract for 2 months in male genital warts had similar effects when compared with cryotherapy [73]. Alternatively, an allicin-containing preparation also was tested for its ability to prevent the common cold, and the results revealed a great ability to avoid the common cold virus attack [74].…”