A clinical study of 205 patients with oral lichen planus

Bagán-Sebastián, J.V.; Milián-Masanet, M.A.; Peñarrocha-Diago, María; Jiménez, Yolanda

doi:10.1016/0278-2391(92)90354-3

Cited by 99 publications

(94 citation statements)

References 16 publications

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“…Oral lichen planus is a chronic inflammatory and autoimmune disease (1), affecting approximately 1 to 2% of the population (2), mainly females, and manifesting most frequently during the fifth and sixth decades of life (3). It is currently considered a disease of unknown etiology and with a multifactorial pathogenesis (1).…”

Section: Introductionmentioning

confidence: 99%

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Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Fernández-González

R²,

Reboiras-López³

et al. 2011

Med Oral

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Objectives: To highlight the most characteristic histopathological findings of oral lichen planus and their correlation with the clinical manifestations and forms. Study design: We performed a retrospective study of 50 biopsied and diagnosed cases of oral lichen planus obtained over a period of 11 years, spanning from May 1998 to April 2009. We analyzed the age and sex of the patient, type of lichen planus, location and different histopathological findings, comparing them with the clinical lesions. Results: Seventy eight percent of the patients are female and 22% are male, with an average age of 56.06 years for both sexes. The most frequent clinical form is reticular, present in 78% of the cases, and the most common location is the buccal mucosa, present in 70% of the patients. Hydropic degeneration of the basal layer and lymphocytic infiltration in the subepithelial layer are observed in the entire sample. Signs of atypia were identified in 4% of the cases, but without dysplasic features. Other common histological findings were the presence of necrotic keratinocytes (92%), hyperplasia (54%), hyperkeratosis (66%), acanthosis (48%), and less frequently, serrated ridges (30%) and the presence plasma cells (26%). Conclusions: Oral lichen planus is a disease that is more common in women, usually appearing in the fifth and sixth decades of life. The most common clinical form is reticular, manifesting mainly in the buccal mucosa. Histological findings characteristic of oral lichen planus include hydropic degeneration of the basal layer, lymphocytic infiltration in the subepithelial layer and the absence of epithelial dysplasia; however, it is also frequent to observe hyperplasia phenomena at the epithelial level, hyperkeratosis, acanthosis and the presence of necrotic keratinocytes.

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Section: Introductionmentioning

confidence: 99%

“…In general, oral lesions usually appear before skin lesions, and sometimes the lesions only appear orally (5). In the mouth, the area most commonly affected is the buccal mucosa, although it may also manifest on the tongue, gingiva and/or the palate (3). Various clinical classifications of oral lichen planus have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Fernández-González

R²,

Reboiras-López³

et al. 2011

Med Oral

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“…It is observed mainly in middle-aged women, and affects 0.1-4% of the general population (1). Bagán et al (2) classify the disorder as white OLP in the presence of reticular or plaque lesions, and as red OLP in the presence of atrophic or erosive lesions, independently of whether or not these coincide with reticular lesions at the periphery or in other locations. The reticular forms are characterized by the presence of whitish streaks known as Wickham striae, typically located on the buccal mucosa.…”

Section: Introductionmentioning

confidence: 99%

“…In some areas, this thin epithelium can become fragmented and give rise to the erosive form. Regarding the histology, the most characteristic findings are the presence of a T lymphocyte and macrophage infiltrate forming a subepithelial band, and hydropic degeneration of the basal layer (2). Although the precise etiology of OLP is unknown, in most cases a multifactorial process is considered to be involved, with the participation of genetic, psychological and infectious factors.…”

Section: Introductionmentioning

confidence: 99%

Clinical features of oral lichen planus. A retrospective study of 65 cases

Torrente-Castells¹,

Figueiredo²,

Berini-Aytés³

et al. 2010

Med Oral

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Objectives: To describe the clinical features of patients diagnosed with oral lichen planus (OLP) and to establish the prevalence of its malignant transformation in our setting. Study design: A retrospective study was made of 65 patients clinically and histologically diagnosed with OLP in the Service of Oral Surgery (Dental Clinic of the University of Barcelona, Spain) in the period 1990-2005. A descriptive and bivariate statistical analysis was made. Results: The mean patient age was 59 years (SD ± 14.9). Most of the patients (61%) were women, and the most frequent location of the lesions was the buccal mucosa (90.8%). White forms of OLP were noted in 66% of the cases, and 46.2% of the patients reported symptoms of some kind. The patients diagnosed with diabetes mellitus (20%) showed a larger proportion of red lesions (p=0.088). No statistically significant association was observed between chronic liver disease and the OLP lesion types or symptoms. Two cases of squamous cell carcinoma were identified in two patients previously or simultaneously diagnosed with OLP. A statistically significant correlation was observed between dysplastic changes / malignization of the lesions and smoking habit (p=0.019). An association to alcohol abuse was also noted, though in this case statistical significance was not reached (p=0.085). Conclusions: The clinical features of our study population were similar to those described in other studies. Diabetic patients with OLP were seen to be more susceptible to the development of atrophic-erosive lesions. Smokers and/or patients with alcohol abuse in turn showed a greater tendency to develop dysplastic changes / malignization in the histopathological study of the lesions.

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“…Buccal mucosa is a common site affected by this disease for both types of reticular and erosive OLP, while the tongue, gingiva, lip and palate are predominantly affected by erosive type. 12 Although the etiopathogenesis is uncertain, physical stress appeared to be an important etiologic factor in 90% of OLPs. 8 In addition, foods, dental procedures, systemic diseases, and poor oral hygiene have also been indicate as precipitating factors of OLP.…”

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confidence: 99%

Pigmented oral lichen planus: A case report

Hartanto

Kallarakal

2017

Sci Dent J

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Background: Lichen planus is a chronic muccocutaneous inflammatory disorder. Oral lichen planus (OLP) has certain specific characteristics in its clinical presentation, but can also be presented in forms resembling other diseases. This may introduce difficulty in the diagnostic process. It has been reported that OLP affects between 0.1 to 4% individuals, predominantly women and people over 40 years old. Case Report: A 46-yearold woman complained of a non-healing ulcer present for 1.5 months. Intraorally, multiple white striae with prominent central areas of brownish hyperpigmentation were apparent on the right and left buccal mucosa, right and left buccal sulcus, and lateral and dorsum of the tongue. A biopsy was completed and the histopathology features confirmed the diagnosis of OLP. For the initial treatment, a topical corticosteroid was prescribed, followed by steroid mouthwash. Response to this treatment was positive. OLP has been frequently reported to affect women over the age of 40, with psychological stress as a primary predisposing factor. The clinical presentation is characteristic of Wickham's striae with erosive areas. However, a biopsy and histopathological examination is mandatory to confirm the diagnosis. The clinical feature of pigmented OLP has been reported and confirmed by microscopic finding of band-like lymphocytic appearance which is the pathognomonic features of OLP, along with basal cell liquefaction degeneration, and melanin in continence at the lamina propria. Conclusion: Pigmented OLP is a variant of erosive OLP. Anamnesis, clinical presentation, and histopathological examination confirm diagnosis.

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A clinical study of 205 patients with oral lichen planus

Cited by 99 publications

References 16 publications

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Clinical features of oral lichen planus. A retrospective study of 65 cases

Pigmented oral lichen planus: A case report

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