A Clinical Randomized Trial Comparing the Cycloplegic Effect of Cyclopentolate Drops Applied to Closed Eyelids Versus Open Eyelids

Zurevinsky, Jocelyn; Sawchuk, Kallie; Lim, Hyun J.; Lee, Chel Hee; Rubab, Shehla

doi:10.3368/aoj.66.1.114

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…In a study of glaucoma patients, self-dosing a drop of topical medication to the closed eyelid in a supine position and allowing the drop to gather in the medial canthus before eyelid opening to deliver the medication to the ocular surface produced similar reductions in intraocular pressure as clinical-dosed medication in typical fashion [143]. Similarly, eyelid versus corneal administration produced comparable cycloplegia in amblyopic children treated with cyclopentolate [144].…”

Section: Alternative Techniquesmentioning

confidence: 96%

Identifying and addressing common contributors to nonadherence with ophthalmic medical therapy

Hovanesian

Singh²,

Bauskar³

et al. 2023

Current Opinion in Ophthalmology

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Purpose of reviewTo discuss common reasons for nonadherence and review existing and emerging options to reduce nonadherence with ocular medical therapy and optimize therapeutic outcomes.Recent findingsNonadherence can arise from patient-related issues (e.g. physical, cognitive) and healthcare-related issues (e.g. cost, access to care). Multiple strategies have been developed and evaluated to overcome these barriers to adherence. Identifying nonadherence and its cause(s) facilitates the development of strategies to overcome it.SummaryMany common causes of nonadherence can be mitigated through a variety of strategies presented.

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Section: Alternative Techniquesmentioning

confidence: 96%

Identifying and addressing common contributors to nonadherence with ophthalmic medical therapy

Hovanesian

Singh²,

Bauskar³

et al. 2023

Current Opinion in Ophthalmology

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show abstract

“…As standard, we set full dilation in 90% within 30 min, i.e. the level expected for blue irides with a single CP drop [4].…”

mentioning

confidence: 99%

Time to drop the phenylephrine from the paediatric cycloplegia protocol: informing practice through audit

Llewellyn

Khandelwal

Glaze

et al. 2018

Eye

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Novel Zeolite Modified Carbon Paste Electrode for Differential Pulse Voltammetric Assay of Cyclopentolate hydrochloride

Al‐Qahtani¹

2021

International Journal of Electrochemical Science

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Cyclopentolate (CLO) is an antimuscarinic compound with actions similar to atropine which induces both mydriasis and paralysis of the ciliary muscle. The present work describes the fabrication of novel carbon paste electrodes (CPE) incorporated with zeolite as a promising analytical protocol for sensitive voltammetric assay of cyclopentolate. Remarkable enhancement of the sensitivity towards CLO was achieved compared with the blank electrode. An irreversible oxidation process with the two-electron transfer was reported elucidated with molecular orbital calculations. The recorded peak currents were linearly proportional to the CLO within the concentration range 48.03 to 725.00 ng mL -1 with LOD of 14.53 ng mL -1 . High sensitivity, fabrication reproducibility, and stability were achieved. Noticeable resolution between the cyclopentolate and phenylephrine voltammetric peaks offers simultaneous assay of cyclopentolate in different pharmaceutical formulations in presence of phenylephrine, excipients, or CLO degradation products. The achieved sensitivity and selectivity demonstrate the applicability of zeolite based sensor for determination of cyclopentolate with average recoveries agreeable with the official pharmacopeial methods.

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A Clinical Randomized Trial Comparing the Cycloplegic Effect of Cyclopentolate Drops Applied to Closed Eyelids Versus Open Eyelids

Abstract: Placing one drop of cyclopentolate HCL 1% on a closed eyelid had a success rate for complete cycloplegia that was equivalent to placing one drop directly on the cornea.

Cited by 4 publications

References 5 publications

Identifying and addressing common contributors to nonadherence with ophthalmic medical therapy

Identifying and addressing common contributors to nonadherence with ophthalmic medical therapy

Time to drop the phenylephrine from the paediatric cycloplegia protocol: informing practice through audit

Novel Zeolite Modified Carbon Paste Electrode for Differential Pulse Voltammetric Assay of Cyclopentolate hydrochloride

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