A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma

Tanrıkulu, Abdullah Çetin; Abakay, Abdurrahman; Kaplan, Mehmet Ali; Küçüköner, Mehmet; Palanci, Yılmaz; Evliyaoğlu, Osman; Sezgı, Cengizhan; Şen, Hadice Selimoğlu; Çarkanat, Ali İhsan; Kırbaş, Gökhan

doi:10.1159/000321370

Cited by 64 publications

(66 citation statements)

References 64 publications

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“…10,11) Indeed, in patients with malignant pleural mesothelioma, it is reported that high WBC count and elevated CRP level associated with poor survival. 12,13) Also, in this patient, the tumor had a very rich blood supply and the prognosis was poor. Although G-CSF production from the mesothelioma cells was not apparent and the levels of other inflammatory cytokines were not measured, an immune response in the area might have contributed to progression of the malignancy.…”

Section: Discussionmentioning

confidence: 78%

Malignant Pleural Mesothelioma Presenting as Acute Empyema with Severe Leukocytosis

Matsuoka

2014

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Five months after the treatment for acute empyema, a 75-year-old woman was referred to our hospital because of marked elevation of the white blood cell (WBC) count and C-reactive protein (CRP) level, and a right pleural mass detected by chest computed tomography. At this time, the WBC count and CRP level had increased to 60400/microl and 18.2 mg/dl, respectively. We performed biopsy and the tumor was diagnosed as sarcomatoid malignant pleural mesothelioma. Malignant pleural mesothelioma occasionally presents the symptoms and findings like an acute empyema. We demonstrated the case of malignant pleural mesothelioma which had presented the symptoms and laboratory findings very similar to acute empyema and had treated as acute empyema.

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Section: Discussionmentioning

confidence: 78%

Malignant Pleural Mesothelioma Presenting as Acute Empyema with Severe Leukocytosis

Matsuoka

2014

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“…With respect to MM, two retrospective screening studies suggested CRP as potent prognostic marker. High levels of serum CRP have been associated with poor prognosis due to the role of chronic inflammation in the development of MM that has been well established (Tanrikulu et al, 2010;Nojiri et al, 2011). A major limitation of all of the staging systems is the difficulty in assessing the extent of disease prior to treatment.…”

Section: Figure 2 Multivariate Analysis Results For Advanced Stage Smentioning

confidence: 99%

Fibulin-3 as a Diagnostic Biomarker in Patients with Malignant Mesothelioma

Kaya

Demir²,

Taylan³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: New tumour biomarkers are being intensely investigated for malignant mesothelioma (MM). Fibulin-3 is produced in MM but its role remains uncertain. The aim of this study was to evaluate the validity of measuring serum fibulin-3 in the diagnosis and prognosis of MM. Materials and Methods: This prospective study was performed on 43 patients and 40 healthy controls who were admitted to our hospital between January 2012 and January 2014. Data from MM patients, including demographic and clinical features, routine laboratory data, levels of serum fibulin-3, and treatment outcomes were defined as potential prognostic factors. The receiver operating characteristic (ROC) curve for fibulin-3 was used to detect the cut-off value with highest sensitivity and specificity. Univariate survival analysis was performed using the Kaplan-Meier method in patients with MM. Afterwards, the possible factors identified with univariate analyses were entered into the cox regression analysis. Results: Our results revealed that patients with MM had significantly higher serum levels of fibulin-3 than controls. The results showed that the best cut-off point was 36.6 ng/ml with an AUC (area under the curve)=0.976, sensitivity=93.0% and specificity=90.0. In our study, the initial significant poor prognostic factors were advanced stage, high white blood cell count, high platelet count, high C-reactive protein (p<0.05 for each variable). Later, according to multivariate analysis the results showed only advanced stage as significant parameter (p=0.040). Conclusions: We determined that real use for serum fibulin-3 was not for prognosis but for diagnosis in MM. Also advanced stage was associated with poor MM prognosis.

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“…5 LDH level was determined in serum using heparin and citrate and an autoanalszer, (Architect 1600c, Abbott Laboratories, Irving, TX, USA). LDH level was measured in tubes with K2 ethylenediaminetetra-acetic acid.…”

Section: Potential Prognostic Parametersmentioning

confidence: 99%

The value of inflammatory parameters in the prognosis of malignant mesothelioma

et al. 2014

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Objective: This study investigated the relationship between potential prognostic parameters that may be associated with increased inflammation and survival in patients with malignant mesothelioma (MM). Methods: This retrospective study assessed potential prognostic parameters measured at the time of MM diagnosis. Data on asbestos exposure, histopathological subtype of MM and laboratory parameters were collected. Results: In 155 patients with MM (90 male), mean survival time was 13.9 months. In univariate analysis, age !60 years and neutrophil-to-lymphocyte ratio (NLR) !3 were associated with significantly shortened median survival times. In multivariate analysis, nonepithelial subtype, red cell distribution width (RDW) !20% and NLR !3 were associated with significantly shortened median survival times. Mortality rate was increased 2.77-, 1.67-and 1.52-fold in patients with RDW !20%, NLR !3 and nonepithelial subtype, respectively. Nonepithelial subtype, white blood cell count !11 200 ml and platelet-to-lymphocyte ratio !300 at baseline were associated with a heightened NLR value. Conclusions: The NLR and RDW were significant predictive factors for MM prognosis.

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A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma

Cited by 64 publications

References 64 publications

Malignant Pleural Mesothelioma Presenting as Acute Empyema with Severe Leukocytosis

Malignant Pleural Mesothelioma Presenting as Acute Empyema with Severe Leukocytosis

Fibulin-3 as a Diagnostic Biomarker in Patients with Malignant Mesothelioma

The value of inflammatory parameters in the prognosis of malignant mesothelioma

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