A Clinical Prediction Rule to Determine Outcomes in Patients with Cervical Spondylotic Myelopathy Undergoing Surgical Treatment: Data from the Prospective, Multicenter AOSpine North America CSM Study

Tetreault, Lindsay; Kopjar, Branko; Arnold, Paul M.; Vaccaro, Alexander R.; Massicotte, Eric M.; Fehlings, Michael G.

doi:10.1016/j.spinee.2013.07.077

Cited by 45 publications

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“…Studies suggest that miRNAs are essential in the regulation of inflammatory signaling pathways and pathological immune responses. Changes in the levels of lots of miRNAs occur after spinal cord injury, which are believed to be involved in immune responses such as invasion of immune cells and regulation of inflammatory signaling pathways [19][20][21]. In this study, miR-544a was screened by microarray for differential expression levels after spinal cord injury.…”

Section: Discussionmentioning

confidence: 99%

miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4

Yang

Chen

et al. 2018

Cell Physiol Biochem

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Background/Aims: To explore the potential role of miR-544a in spinal cord injury and the possible mechanism involved. Methods: We established a mouse model with spinal cord injury to examine the changes in grip force recovery of the forelimb or the posterior limb of the mouse. Microarray was performed to achieve differentiated miRNAs in the mice. The expressions of miR-544a, MCP-1, IL36B and IL17B after spinal cord injury were detected by qRT-PCR. Subsequently, miR-544a was overexpressed to observe changes in inflammation and grip strength after spinal cord injury. Target gene of miR-544a was then predicted using bioinformatics technology. Finally, dual luciferase reporter gene assay was used to verify the binding of miR-544a to its target gene. Results: Using mice models with spinal cord injury, we found that the strength of their four limbs began to recover 7 days after injury. The results of microarray and qRT-PCR confirmed that mir-544a level in mice with spinal cord injury decreased with increase of injury time, while the levels of inflammatory genes MCP-1 (monocyte chemoattractant protein-1), IL1 (interleukin-1) and TNF-α (tumor necrosis factor alpha) IL36B (interleukin-36 beta) and IL17B (interleukin-17 beta) were significantly increased. However, overexpression of miR-544a in the mice significantly reduced the level of inflammation and restored their grip strength in their four limbs. Finally, we found that miR-544a can bind to the NEUROD4 (Neurogenic differentiation 4) 3’UTR (Untranslated Region) region through bioinformatics website prediction, which was further confirmed by dual luciferase reporter assay. NEUROD4 level was significantly reduced following the overexpression of miR-544a. Conclusion: The expression of miR-544a was significantly decreased after spinal cord injury. High expression of miR-544a could alleviate the inflammation caused by spinal cord injury and promote the recovery of spinal cord via the inhibition of NEUROD4.

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Section: Discussionmentioning

confidence: 99%

miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4

Yang

Chen

et al. 2018

Cell Physiol Biochem

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“…Advanced age (older than 65 years) was confirmed to be associated with an increased morbidity and mortality rate [OR (CI) 1.65 (1.57-1.72) and 2.74 (2.25-3.34), respectively]. Several studies have reported advanced age as an independent risk factor for post-operative complications [6,8,[19][20][21][22]. Holly et al [19] reported a series of 36 patients older than 75 years with CSM who underwent surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

Predictors of morbidity and mortality among patients with cervical spondylotic myelopathy treated surgically

et al. 2015

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“…Tetreault and colleagues were the first to evaluate predictors of surgical outcome using linear regression in symptomatic patients with cervical spondylotic myelopathy [22]. Their study findings showed that greater severity scores, smoking, older age, psychological comorbidities, longer duration of symptoms, smaller transverse spinal cord area, and impaired gait presence were associated with a decreased probability of successful outcomes.…”

Section: Predictive Models Using Logistic Regressionmentioning

confidence: 99%

“…Their study findings showed that greater severity scores, smoking, older age, psychological comorbidities, longer duration of symptoms, smaller transverse spinal cord area, and impaired gait presence were associated with a decreased probability of successful outcomes. One of the strengths of the study that is used is a prospectively acquired cohort of 272 patients that included multiple centers [22]. The limitations of the study included a 20 % loss to follow-up at 1 year [22].…”

Section: Predictive Models Using Logistic Regressionmentioning

confidence: 99%

“…One of the strengths of the study that is used is a prospectively acquired cohort of 272 patients that included multiple centers [22]. The limitations of the study included a 20 % loss to follow-up at 1 year [22]. Also, all the results were in odds ratios, which prevented the ease and ability to translate this information effectively into a practical, point-of-care setting.…”

Section: Predictive Models Using Logistic Regressionmentioning

confidence: 99%

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Predictive modeling of complications

Osorio

Ames

2016

Curr Rev Musculoskelet Med

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Predictive analytic algorithms are designed to identify patterns in the data that allow for accurate predictions without the need for a hypothesis. Therefore, predictive modeling can provide detailed and patient-specific information that can be readily applied when discussing the risks of surgery with a patient. There are few studies using predictive modeling techniques in the adult spine surgery literature. These types of studies represent the beginning of the use of predictive analytics in spine surgery outcomes. We will discuss the advancements in the field of spine surgery with respect to predictive analytics, the controversies surrounding the technique, and the future directions.

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A Clinical Prediction Rule to Determine Outcomes in Patients with Cervical Spondylotic Myelopathy Undergoing Surgical Treatment: Data from the Prospective, Multicenter AOSpine North America CSM Study

Cited by 45 publications

References 0 publications

miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4

miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4

Predictors of morbidity and mortality among patients with cervical spondylotic myelopathy treated surgically

Predictive modeling of complications

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