2013
DOI: 10.1111/pace.12067
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A Clinical Phenotype of Adverse Response to Biventricular Pacing: A Case Series

Abstract: A phenotype of adverse response to biventricular pacing is characterized by relatively narrow QRS duration, RV dysfunction, and pulmonary hypertension. Clinical decline is rapid and associated with the development of RBBB-type morphology, worsening of pulmonary hemodynamics, and RV dysfunction with biventricular pacing.

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“…Similarly, the lack of apparent clinical or echocardiographic improvement should not be misconstrued as the absence of benefit from BiVp, just as apparent progression of heart failure may not indicate a lack of benefit from contemporary neurohormonal antagonists. The identification of these "favorable non-responders" is crucial to avoid inadvertent termination of an effective treatment, just as identification of adverse responders19 would be important to avoid continued delivery of a harmful intervention to patients.The assessment of LV (reverse) remodeling has dominated the BiVp literature 20,21 . Recent reports have highlighted the relevance of right ventricular function in patients with BiVp.…”
mentioning
confidence: 99%
“…Similarly, the lack of apparent clinical or echocardiographic improvement should not be misconstrued as the absence of benefit from BiVp, just as apparent progression of heart failure may not indicate a lack of benefit from contemporary neurohormonal antagonists. The identification of these "favorable non-responders" is crucial to avoid inadvertent termination of an effective treatment, just as identification of adverse responders19 would be important to avoid continued delivery of a harmful intervention to patients.The assessment of LV (reverse) remodeling has dominated the BiVp literature 20,21 . Recent reports have highlighted the relevance of right ventricular function in patients with BiVp.…”
mentioning
confidence: 99%