A Clinical Note on Marchiafava-Micheli Disease

Paroxysmal Nocturnal Haemoglobinuria: Variation in Clinical Severity and Association with Bone‐Marrow Hypoplasia

“…Crosby also stated that in two patients personally studied who had been ill for more than 10 years the disease had become milder and that their erythrocytes were more resistant to haemolysis in vitvo than formerly. Wagley and Rumsfeld (1958) reported an even more striking case; their patient, 32 years after the onset of the disease, was normal clinically and had a completely normal blood picture. The acidified-serum test was, however, still positive (no figures for per cent haemolysis were given).…”

Paroxysmal Nocturnal Haemoglobinuria Parturition Complicated by Presumed Hepatic Vein Thrombosis

“…Pregnancy appears to be rare in patients with paroxysmal nocturnal haemoglobinuria and only 3 of 18 married patients mentioned by Dacie (1967) became pregnant. Miscarriages in patients with this disease have been described before (Witts, 1936;Wagley and Rumsfeld, 1958), and a report by Schiavo and Pennini de Vega (1955) suggested that miscarriage is likely to occur during bouts of severe anaemia. In our patient each of the three miscarriages followed an episode of severe anaemia.…”