A clinical case of multiple amiodarone side effects development

Sivyakova, Ol'ga; Shmanova, N.Yu.; Duleba, A.P.

doi:10.26442/2075-1753_2018.5.71-74

Cited by 5 publications

(2 citation statements)

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“…Нуждается в объяснении повышение плотности печени по фиброскану, снизившаяся через полгода после отмены амиодарона. По данным литературы поражение печени встречается при частом внутривенном введении амиодарона, однако в нашем наблюдении инъекции использовались крайне редко [6,7].…”

Section: Discussionunclassified

“…Полинейропатия развивается при длительном, более года приёме амиодарона в дозе 400 мг/сутки и более и манифестирует интенсивными болями в дистальных, а иногда и проксимальных отделах ног. Нередко полинейропатия сочетается с клиникой повреждения центральной нервной системы, миопатией, дерматитом [2,6]. При гистологических исследованиях выявляется демиелинизирующая аксонопатия.…”

Section: Discussionunclassified

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Options of organopatology in long-term use of amiodarone

Atamanov

2023

jour

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A patient with paroxysmal atrial fibrillation has been taking amiodarone for 20 years with short breaks in order to maintain sinus rhythm or restore it. His disease was complicated by iatrogenic, drug-induced complications in the liver, peripheral and central nervous system, speech motility, thyroid gland, and skin. Cancellation of amiodarone contributed to the relief of organ complications of taking this drug after 3-6-9 months.

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Section: Discussionunclassified

Options of organopatology in long-term use of amiodarone

Atamanov

2023

jour

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Amiodaron-induced skin lesion: focus on blue man syndrome

Trukhan

2023

Medicinskij sovet

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Amiodarone has been used in clinical practice since 1964. The 2020 European guidelines note that amiodarone is recommended for long-term rhythm control in all patients with atrial fibrillation. However, due to its extracardiac toxicity, other antiarrhythmic drugs should be considered first. Information databases were searched for descriptions of amiodarone-induced blue man syndrome. Its pathogenesis is associated with accelerated physiological aging of dermal cells, leading to the accumulation of lipofuscin in lysosomes, or occurs as a result of the direct accumulation of amiodarone and its metabolites in the skin. As part of the review, brief descriptions of the 32 clinical cases found of the blue man syndrome are given. Most publications refer to various countries in Europe and the United States, which suggests that this syndrome develops more often in Caucasians. This syndrome is more common in people over 60 years of age, males predominate among patients. The development of the blue man syndrome is preceded by long-term use of amiodarone and the achievement of a certain cumulative dose. After the abolition of amiodarone, a gradual improvement is noted for 1 year or more. Other side effects of amiodarone are often detected in the presence of the blue man syndrome. Most publications describing the blue man syndrome belong to cardiologists and dermatologists. Given the variety of side effects of amiodarone, pulmonologists, endocrinologists, neurologists, ophthalmologists, gastroenterologists and doctors of other specialties may encounter a blue-gray skin color change.

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Клінічні Випадки Токсичного Ураження Очей На Фоні Застосування Антиаритмічного Препарату Аміодарон

Lavryk¹,

Zinchenko²,

Mikhaleva³

et al. 2023

AOU

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Аміодарон — один із найбільш широко застосовуваних антиаритмічних препаратів. Незважаючи на високу фармакологічну ефективність, аміодарон має широкий спектр ускладнень, як кардіальних, так і екстракардіальних. Аміодароніндуковані дисфункції легень, щитоподібної залози, печінки та інших органів є приводом до відміни препарату. Можливість розвитку офтальмологічних порушень унаслідок використання препарату потребує обов’язкового динамічного спостереження офтальмологом таких пацієнтів.

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A clinical case of multiple amiodarone side effects development

Cited by 5 publications

References 0 publications

Options of organopatology in long-term use of amiodarone

Options of organopatology in long-term use of amiodarone

Amiodaron-induced skin lesion: focus on blue man syndrome

Клінічні Випадки Токсичного Ураження Очей На Фоні Застосування Антиаритмічного Препарату Аміодарон

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